Results 31 to 40 of about 2,252,807 (303)

Role of phosphoinositide 3-kinases in mast cell activation [PDF]

, 2009
Mast cells are primary effector cells in allergy and chronic inflammation. Class IB (PI3Kγ) and class IA (PI3Kδ) PI3K have been shown to play major roles in mast cell activation: antigen/IgE stimulation triggers autocrine/paracrine activation of mast ...
Collmann, Emilie
core   +1 more source

Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Cells, 2023
Lipopolysaccharide (LPS) stimulates dual receptor signaling by bridging the B cell receptor and Toll-like receptor 4 (BCR/TLR4). B cells from IκBNS-deficient bumble mice treated with LPS display reduced proliferative capacity and impaired plasma cell ...
Monika Adori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquin Castro Dopico, Gunilla B. Karlsson Hedestam   +4 more
doaj   +1 more source

Multiple regulatory mechanisms control B-1 B cell activation

Frontiers in Immunology, 2012
B-1 cells constitute a unique subset of B cells identified in several species including mice and humans. B-1 cells are further subdivided into B-1a and B-1b subsets as the former but not the later express CD5.
Vishal eSindhava, Subbarao eBondada
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Lymphocyte activation gene-3 : the expression and function in the immune system [PDF]

, 2006
Lymphocyte activation gene-3 (LAG-3) is the structural homologue of a well-known TCR co-receptor CD4. Recently, it has been suggested that LAG-3 might play a role in modulation of immune response, by being a negative regulator of T cell activation. To
Kisielow, Malgorzata
core   +1 more source

Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul

Frontiers in Immunology, 2018
This article describes the work I did in Bill Paul’s lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill’s lab at ...
Anthony L. DeFranco
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Dengue Virus Directly Stimulates Polyclonal B Cell Activation.

PLoS ONE, 2015
Dengue infection is associated to vigorous inflammatory response, to a high frequency of activated B cells, and to increased levels of circulating cross-reactive antibodies.
Arturo Ramon Vargas Correa, Ana Carolina Egypto Rosa Berbel, Michelle Premazzi Papa, Ana Theresa Silveira de Morais, Ligia Maria Torres Peçanha, Luciana Barros de Arruda   +5 more
doaj   +1 more source

Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation. [PDF]

PLoS ONE, 2014
OBJECTIVES: To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect.
Angela Bikker, Aike A Kruize, Kim M G van der Wurff-Jacobs, Rogier P Peters, Marije Kleinjan, Frank Redegeld, Wilco de Jager, Floris P J G Lafeber, Joël A G van Roon   +8 more
doaj   +1 more source

Advancements in understanding the regulatory mechanism of B-cell immune activation associated with adenotonsillar hypertrophy

生物医学转化
B cells play a crucial role in recognizing external antigens through their surface B cell receptor (BCR), essential for generating protective antibodies and immune memory.
Chen Wenjing, Gao Ruiyu, Huang Jingwen, Ye Jingying, Liu Wanli   +4 more
doaj   +1 more source