Results 41 to 50 of about 2,252,807 (303)

Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates. [PDF]

PLoS ONE, 2016
The immunological synapse (IS), a dynamic and organized junction between T-cells and antigen presenting cells (APCs), is critical for initiating adaptive immunity.
Bo-Ra Na, Min-Sung Kwon, Myoung-Won Chae, Hye-Ran Kim, Chang-Hyun Kim, Chang-Duk Jun, Zee-Yong Park   +6 more
doaj   +1 more source

Conditional immortalization of human B cells by CD40 ligation [PDF]

, 2008
It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C., Caroline Zentz, Reinhard Zeidler, Hammerschmidt, W., Wolfgang Hammerschmidt, Wiesner, Martina, Wimmer, Rainer, Wiesner, M., Christine Mayr, Hammerschmidt, Wolfgang, Zentz Caroline, Zentz, C., Moosmann, A., Zeidler, Reinhard, Wiesner Martina, Moosmann Andreas, Andreas Moosmann, Mayr Christine, Wimmer, R., Wimmer Rainer, Zentz, Caroline, Hammerschmidt Wolfgang, Mayr, Christine, Martina Wiesner, Moosmann, Andreas, Rainer Wimmer, Zeidler Reinhard, Zeidler, R.   +27 more
core   +1 more source

Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis

Frontiers in Immunology, 2018
Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of ...
Christian Schmidt, Christian Schmidt, Thilo Berger, Marcus Groettrup, Marcus Groettrup, Marcus Groettrup, Michael Basler, Michael Basler, Michael Basler   +8 more
doaj   +1 more source

Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection. [PDF]

, 2011
BACKGROUND: Dengue virus is transmitted by mosquitoes and has four serotypes. Cross-protection to other serotypes lasting for a few months is observed following infection with one serotype.
Low, Jenny G., Bela-Ong, D.B., Gu, F., Martin L. Hibberd, Fink, Katja, Mickey B Koh, Hibberd, Martin, L, Martin L Hibberd, Katja Fink, Ooi Eng Eong, Leo Yee Sin, Toh, Ying, Xiu, Balakrishnan, Thavamalar, Jenny G Low, Leo, Yee Sin, Balakrishnan, T., Devi, S., Toh Ying Xiu, Dennis B Bela-Ong, Marie Flamand, Flamand, M., Hibberd, Martin L., Flamand, Marie, Leo, Y.S., Flamand Marie, Devi Shamala, Bela-Ong, Dennis, B, Thavamalar Balakrishnan, Yee Sin Leo, Fink Katja, Fink, K., Hibberd, M.L., Jenny G. Low, Ying Xiu Toh, Ooi, E.E., Toh, Y.X., Gu Feng, Ooi, Eng, Eong, Leo, Yee, Sin, Koh, Mickey B., Hibberd Martin L., Bela-ong, Dennis B., Koh, Mickey, B, Eng Eong Ooi, Feng Gu, Low, J.G., Dennis B. Bela-Ong, Balakrishnan Thavamalar, Low, Jenny G, Low Jenny G., Shamala Devi, Toh, Ying Xiu, Bela-Ong, Dennis B, Low, Jenny, G, Mickey B. Koh, Koh Mickey B., Devi, Shamala, Ooi, Eng Eong, Hibberd, Martin L, Koh, M.B., Bela-Ong Dennis B., Koh, Mickey B, Gu, Feng   +62 more
core   +1 more source

Tumor-derived autophagosomes (DRibbles) induce B cell activation in a TLR2-MyD88 dependent manner. [PDF]

PLoS ONE, 2013
Previously, we have documented that isolated autophagosomes from tumor cells could efficiently cross-prime tumor-reactive naïve T cells and mediate tumor regression in preclinical mouse models. However, the effect of tumor-derived autophagosomes, here we
Weixia Li, Meng Zhou, Hongyan Ren, Hong-Ming Hu, Liwei Lu, Meng Cao, Li-xin Wang   +6 more
doaj   +1 more source

B-cell activity in children with malaria [PDF]

Malaria Journal, 2012
AbstractBackgroundRecent studies implicate deficiency of red blood cell (RBC) complement regulatory proteins (CR1 and CD55) in the pathogenesis of malarial anaemia. This study explored the involvement of B cell CD21, which has an analogous role to RBC CR1.MethodsIn a case control study conducted in Kisumu District hospital, western Kenya, children with
Korir Jackson C, Magambo Japhet K, Mwatha Joseph K, Waitumbi John N   +3 more
openaire   +3 more sources

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M, Cerutti, A, Andrea Cerutti, Puga, I, Montserrat Cols, Irene Puga   +5 more
core   +1 more source

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

Nature Communications
Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive.
Tea Babushku, Markus Lechner, Stefanie Ehrenberg, Ursula Rambold, Marc Schmidt-Supprian, Andrew J. Yates, Sanket Rane, Ursula Zimber-Strobl, Lothar J. Strobl   +8 more
doaj   +1 more source

Regulation of murine B cell development and function [PDF]

, 2011
Vertebrates have developed an effective and protective, yet complex and dynamic immune system to defend themselves against the many threats from microorganisms.
Flück, Lukas Andreas
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source