Results 41 to 50 of about 19,601 (224)
Frontiers in Medicine, 2021 Background: Biliary atresia (BA) is considered to be an autoimmune-mediating inflammatory injury. The pathogenesis of BA has been proposed with the clonal transformation of T cells expressing analogous T-cell receptor β-chain variable regions (TRBVs ...
Jing Ye +7 more
doaj +1 more source
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
Nature Immunology, 2003 T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and ...
Reiser, J +9 more
openaire +2 more sources
Development of TCRB CDR3 length repertoire of human T lymphocytes [PDF]
International Immunology, 2004 The third complementarity-determining region (CDR3) of TCR interacts directly with antigenic peptides bound to grooves of MHC molecules. Thus, it is the most critical TCR structure in launching acquired immunity and in determining fates of developing thymocytes.
Junko, Nishio +4 more
openaire +2 more sources
Engineered Bovine Antibodies in the Development of Novel Therapeutics, Immunomodulators and Vaccines
Antibodies, 2014 Some bovine antibodies across all classes are unique, such as the CDR3 of the variable heavy-domain (VH CDR3), which is exceptionally long (up to 66 amino acids), unlike most conventional antibodies where the VH CDR3 loops range from 10 to 25 amino acids.
Madhuri Koti +3 more
doaj +1 more source
Research progress on the T cell receptor CDR3 spectral sequence of periodontitis
口腔疾病防治, 2019 Periodontitis is a chronic inflammatory and destructive disease of periodontal support tissue initiated by plaque microorganisms, and its pathogenesis and progression are closely related to the immune response of the host, in which T cells play an ...
WANG Min, GE Song
doaj +1 more source
, 2017 Distribution of the CDR3 amino acid (aa) lengths frequencies for the clonotypes forming the epitope-specific CD8 T cell repertoire for (A) three SR/SR patients and (B) two SR/CI patients pre-, at the peak and post/late the reinfection episode. Non-linear
Mohamed S. Abdel-Hakeem (3710941) +4 more
core +1 more source
Arquivos de Neuro-Psiquiatria, 2005 OBJECTIVE: To compare magnetic resonance proton spectroscopic with clinical data and to propose a spectroscopic staging of Alzheimer's disease (AD). METHOD: Subjects (n=46), normals (12) and with AD (34), paired to age (CDR0-CDR3); AD diagnosis according
Eliasz Engelhardt +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Gut microbes play a crucial role in the occurrence and development of autoimmune diseases. The diversity of intestinal microorganisms affected by the living environment, regulate the immune function of peripheral immune organs and local tissues.
Jun Li +7 more
doaj +1 more source
, 2012 Conserved CDR3 sequences from β chain of T cells exhibited a single peak on CDR3 spectratype analysis.
Qi Jin (12159) +10 more
core +1 more source
, 2022 Additional file 1: Supplementary Table 1. The frequency of IGHV genes usage. Supplementary Table 2. The frequency of IGHD genes usage. Supplementary Table 3. The frequency of IGHJ genes usage. Supplementary Table 4. The combined usage frequencies of IGHV
Zhiwen Xu (28724) +9 more
core +1 more source