Results 61 to 70 of about 19,601 (224)
Advanced Science, EarlyView.A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li +14 more
wiley +1 more source
The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter [PDF]
Journal of Bacteriology, 1997 We report the cloning and functional analysis of a third member of the CDR gene family in Candida albicans, named CDR3. This gene codes for an ABC (ATP-binding cassette) transporter of 1,501 amino acids highly homologous to Cdr1p and Cdr2p (56 and 55% amino acid sequence identity, respectively), two transporters involved in fluconazole resistance in C.
I, Balan, A M, Alarco, M, Raymond
openaire +2 more sources
Advanced Science, EarlyView.Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu +13 more
wiley +1 more source
, 2015 Bold: CDR3 sequence of NY-ESO-1-specific CTL clonesThe 15 most frequent CDR3 sequences in the pretreatment PBMCs and dominant CDR3 sequences of NY-ESO-1-specific CD8 T cell clones.
Manami Miyai (785493) +10 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang +9 more
wiley +1 more source
T cells to a dominant epitope of GAD65 express a public CDR3 motif [PDF]
International Immunology, 2006 Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes, and serve as a model for type 1 diabetes (T1D) and natural autoimmunity. T cell responses to the pancreatic islet antigen glutamic acid decarboxylase 65 (GAD65) can be detected in the spleens of young prediabetic NOD mice, which display a unique MHC class II molecule.
Anthony, Quinn +6 more
openaire +2 more sources
New insights into the Germline Genes and CDR3 Repertoire of the TCRβ chain in Chiroptera
Frontiers in Immunology, 2022 Abstract Bats are known to be natural reservoirs of many viruses, yet their unique immune system enables them to coexist with viruses without frequently exhibiting disease symptoms. The current understanding of the bat adaptive immune system is limited, as there is no database or tool capable of processing T-cell receptor (TCR ...
Hao Zhou +9 more
openaire +3 more sources
Solvent accessible areas of CDR3 D7 residues.
, 2013 Solvent accessible areas of CDR3 D7 residues.
David Lutje Hulsik (177480) +9 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi +11 more
wiley +1 more source
CDR3 bulk characteristics in Treg of patients and healthy controls.
, 2019 A). nucleotide length of CDR3 segment B). NDN nucleotides size C). V-D and D-J insert size. NDN and CDR3 length in cases and controls showed same distribution for Treg and total lymphocytes.
Alfredo Rossi (564968) +7 more
core +1 more source