Results 71 to 80 of about 19,601 (224)

Heavy and light chain CDR3 lengths of cases at T1 and T2.

, 2022
CDR3H amino acid length from case individuals at T1 (A) and T2 (B). Light chain CDR3 lengths from case individuals at T1 (C) and at T2 (D). Distribution of functional clone size was calculated as the average proportion of functional clones for each ...
Jolyon Martin (13020735), Steven G. Friedenberg (9553318), Albert J. Vilella (13020738), David Sargan (7063688), Allan Bradley (30345), Jonah N. Cullen (5394503), Amy Treeful (13020741)   +6 more
core   +1 more source

Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after hepatitis B vaccination

Human Vaccines & Immunotherapeutics, 2019
The hepatitis B (HB) vaccine effectively prevents the incidence of hepatitis B virus (HBV) infection. However, vaccine failure occurs in 5–10% of the recipients.
Akio Miyasaka, Yuichi Yoshida, Ting Wang, Yasuhiro Takikawa   +3 more
doaj   +1 more source

Integrating Immunotherapy Into Head and Neck Surgery: Bridging Tumor Biology to Perioperative Decision‐Making, a Review

Head &Neck, EarlyView.
ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley   +1 more source

Mycoplasma Superantigen Is a CDR3-dependent Ligand for the T Cell Antigen Receptor [PDF]

The Journal of Experimental Medicine, 1998
Superantigens are defined as proteins that activate a large number of T cells through interaction with the Vβ region of the T cell antigen receptor (TCR). Here we demonstrate that the superantigen produced by Mycoplasma arthritidis (MAM), unlike six bacterial superantigens tested, interacts not only with the Vβ region but also with the CDR3 (third ...
A S, Hodtsev, Y, Choi, E, Spanopoulou, D N, Posnett   +3 more
openaire   +2 more sources

Known specificity human TCR CDR3 sequences

, 2014
The hypervariable complementarity determining region 3 (CDR3) of T-cell receptors (TCRs) forms the major contacts with the peptide-MHC molecule, and thus is the key site of determining antigen specificity.
James M. Heather (412058)
core   +1 more source

Hydrophobic CDR3 residues promote the development of self-reactive T cells [PDF]

Nature Immunology, 2016
Studies of individual T cell antigen receptors (TCRs) have shed some light on structural features that underlie self-reactivity. However, the general rules that can be used to predict whether TCRs are self-reactive have not been fully elucidated.
Stadinski, Brian D, Shekhar, Karthik, Gómez-Touriño, Iria, Jung, Jonathan, Sasaki, Katsuhiro, Sewell, Andrew K, Peakman, Mark, Chakraborty, Arup K, Huseby, Eric S   +8 more
openaire   +6 more sources

Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

mAbs, 2020
During the development of a therapeutic monoclonal antibody (mAb-1), the charge variant profile obtained by pH-gradient cation exchange chromatography (CEX) contained two main peaks, each of which exhibited a unique intrinsic fluorescence profile and ...
Wenkui Lan, Joseph J. Valente, Andrew Ilott, Naresh Chennamsetty, Zhihua Liu, Joseph M. Rizzo, Aaron P. Yamniuk, Difei Qiu, Holly M. Shackman, Mark S. Bolgar   +9 more
doaj   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression

Cancer Informatics, 2023
Introduction: One of the most pressing goals for cancer immunotherapy at this time is the identification of actionable antigens. Methods: This study relies on the following considerations and approaches to identify potential breast cancer antigens: (i ...
Nagehan Pakasticali, Andrea Chobrutskiy, Dhruv N. Patel, Monica Hsiang, Saif Zaman, Konrad J. Cios, George Blanck, Boris I. Chobrutskiy   +7 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source