Results 91 to 100 of about 19,601 (224)
Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions [PDF]
Frontiers in Immunology, 2016 Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper,
Townsend, Catherine Louise +7 more
openaire +6 more sources
Data in Brief, 2018 The highly variable complementary determining region 3 (CDR3) of antibodies is generated through recombination of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes.
Linnea Thörnqvist, Mats Ohlin
doaj +1 more source
Distorted TCR repertoires define multisystem inflammatory syndrome in children.
PLoS ONE, 2022 While the majority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) display mild or no symptoms, rare individuals develop severe disease presenting with multisystem inflammatory syndrome (MIS-C).
Amna Malik +11 more
doaj +1 more source
Cell Proliferation, EarlyView.This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai +15 more
wiley +1 more source
PCA of Kidera Factor representation of unique CDR3 sequences.
, 2014 3D scatterplot on the first three eigenvectors of the Principal Component Space obtained from Kidera Factor representations of the unique CDR3 sequences in the unseparated T cell Female sample.
Martino Barenco (21014) +4 more
core +1 more source
Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation
Cell Proliferation, EarlyView.In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li +14 more
wiley +1 more source
Baseline characteristic and CDR3 scores of TB patients.
, 2012 Baseline characteristic and CDR3 scores of TB patients.
Qi Jin (12159) +10 more
core +1 more source
To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy
European Journal of Haematology, EarlyView.ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino +16 more
wiley +1 more source
Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis
Journal of the European Academy of Dermatology and Venereology, EarlyView.Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs +6 more
wiley +1 more source
MedComm, Volume 7, Issue 7, July 2026.High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai +10 more
wiley +1 more source