Results 101 to 110 of about 19,601 (224)
Cross‐Level Regulatory Interactions Underlying Human Immune Aging
MedComm, Volume 7, Issue 7, July 2026.We performed multi‐omics sequencing on peripheral blood samples from 69 individuals aged 23–75 years and identified multi‐layered molecular interaction networks underlying the process of immune senescence, which provides a comprehensive multi‐omics framework for understanding immune aging and identifying potential strategies to delay immunosenescence ...
Quanyou Wu +9 more
wiley +1 more source
Kinetic of VHCDR3 uptake by PM.
, 2013 PM (1×106/ml) were incubated for different times with b-VHCDR3 or b-NC (all 10 µg/ml). After incubation, permeabilized cells were reacted with FITC-labelled mAb to biotin and analyzed by FACScan flow cytometry.
Federica Ortelli (368707) +9 more
core +1 more source
Example of a comparison of diversities of CDR3 sequences in two samples.
, 2016 Diversity indices of order one are given on the y-axis, CDR3 lengths (amino acids) are on the x-axis. Samples are color coded (blue and red). Dots represent mean diversities of all CDR3 sequences of given length; bars represent standard deviation ...
Saleh M. Ibrahim (85220) +1 more
core +1 more source
Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity
BMC Bioinformatics, 2019 Background Repertoire sequencing is enabling deep explorations into the cellular immune response, including the characterization of commonalities and differences among T cell receptor (TCR) repertoires from different individuals, pathologies, and antigen
Neerja Thakkar, Chris Bailey-Kellogg
doaj +1 more source
Immunological Reviews, Volume 340, Issue 1, July 2026.ABSTRACT Advances in high‐throughput sequencing, single‐cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation of antigen‐specific repertoires at an unprecedented scale.
Kilian Schober
wiley +1 more source
4LCA variable domain usage, CDR3 sequences, and mutation status.
, 2013 CDR3, complementary determining region 3. Muts, mutations in the entire IgG HC and LC variable domains.
Lance L. Simpson (355192) +8 more
core +1 more source
eLife, 2017 Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized.
Asaf Madi +12 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.G Protein‐gekoppelte Rezeptoren (GPCRs) sind wichtige therapeutische Zielstrukturen. Die Modulation der GPCR‐Aktivität über intrazelluläre Bindungsstellen gewinnt zunehmend an Bedeutung. Ein strukturell und computergestützter Ansatz ermöglichte die Entwicklung kleiner, vom G Protein abgeleiteter Peptidomimetika, die gezielt an die intrazelluläre ...
Phuong Thu Tran +11 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran +11 more
wiley +1 more source