Results 111 to 120 of about 19,601 (224)

Example of an analysis of CDR3 amino acid sequence length distribution.

, 2016
a) Percentages (y-axis) of different CDR3 sequence lengths (x-axis) (upper figure). b) Percentages (y-axis) of productive (orange) and unproductive (blue) sequences per CDR3 sequence length (x-axis) (lower figure).
Saleh M. Ibrahim (85220), Julia Bischof (790615)   +1 more
core   +1 more source

Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

eLife
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II.
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov   +7 more
doaj   +1 more source

TNF-α induced TLR-4 expression in PM stimulated with V_HCDR3.

, 2013
PM (5×106/ml) were cultured for 1 h in the presence or absence (NS) of VHCDR3, LPS or NC (all 10 µg/ml).
Federica Ortelli (368707), Stefania Conti (92354), Walter Magliani (92353), Eva Pericolini (290617), Anna Vecchiarelli (290625), Elena Gabrielli (290619), Francesco Bistoni (184196), Luciano Polonelli (92344), Elio Cenci (290621), Tecla Ciociola (309997)   +9 more
core   +1 more source

T Cell Receptor Immune Repertoires Are Promptly Reconstituted After Methicillin-Resistant Staphylococcus aureus Infection

Frontiers in Microbiology, 2019
T cells represent a subset of lymphocytes characterized by immunosurveillance and immunoregulation function. Peripheral blood mononuclear cells (PBMCs) are enriched in T cells, which exert critical antimicrobial roles in infectious diseases.
Jiangjun Liu, Jiangjun Liu, Zhongqiang Liu, Yuanqi Zhu, Bingzi Dong, Zheng Cai, Qing Liang, Kejia Wang   +7 more
doaj   +1 more source

Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies

, 2019
International audienceThe antibody repertoire of Bos taurus is characterized by a subset of variable heavy (VH) chain regions with ultralong third complementarity determining regions (CDR3) which, compared to other species, can provide a potent response ...
Chen, Patricia, Vadnais, Melissa, Criscitiello, Michael, Smider, Vaughn, Torkamani, Ali, Mwangi, Waithaka, Deiss, Thaddeus, Lefranc, Marie-Paule, Wang, Feng   +8 more
core   +1 more source

Shorter TCR β-Chains Are Highly Enriched During Thymic Selection and Antigen-Driven Selection

Frontiers in Immunology, 2019
The adaptive immune system uses several strategies to generate a repertoire of T cell receptors (TCR) with sufficient diversity to recognize the universe of potential pathogens.
Xianliang Hou, Ping Zeng, Xujun Zhang, Jianing Chen, Yan Liang, Jiezuan Yang, Yida Yang, Xiangdong Liu, Hongyan Diao   +8 more
doaj   +1 more source

Diversity of Vβ CDR3 Kidera Factors.

, 2014
The full set of CDR3 Kidera Factors from an unseparated T cell sample was contained in a small fraction of the theoretical total possible diversity bounded by the maximum possible Kidera Factor values for each PCA.
Martino Barenco (21014), Nigel Klein (18890), Michael Epstein (272810), Robin E. Callard (382650), Michael Hubank (21018)   +4 more
core   +1 more source

Overlap of unique CDR3 amino acid sequences by variable for class-switched antibodies.

, 2019
The overlap of unique CDR3 sequences is displayed in Venn Diagrams. The total number of unique CDR3 amino acid sequences is displayed for each variable group with the percent of the shared repertoire shown in italics below the number of unique amino acid
Bailey A. Bye (4752828), Stephen K. Chapes (511392), Nina C. Nishiyama (6240056), Claire Ward (362061), Savannah Hlavacek (6240059), Trisha A. Rettig (4752831), Michael J. Pecaut (461016)   +6 more
core   +1 more source

Unique CDR3 amino acid sequence overlap for TT and CpG treatment groups for class-switched antibodies.

, 2019
The overlap of unique CDR3 amino acid sequences is displayed in Venn Diagrams. The total number of unique CDR3 amino acid sequences in each treatment group, regardless of AOS status, with the percent of the shared repertoire shown in italics below the ...
Bailey A. Bye (4752828), Stephen K. Chapes (511392), Nina C. Nishiyama (6240056), Claire Ward (362061), Savannah Hlavacek (6240059), Trisha A. Rettig (4752831), Michael J. Pecaut (461016)   +6 more
core   +1 more source

Dynamics of HBsAb persistence and associated BCR IgG-H CDR3 repertoire features in ultra-high versus extremely low responders to HBV vaccination

Frontiers in Immunology
ObjectiveThis study aimed to investigate the duration of hepatitis B surface antibody (HBsAb) level maintenance and characterize the corresponding IgG-H CDR3 repertoire in volunteers exhibiting either ultra-high or extremely low HBsAb levels following ...
Ting-Wen Yang, Ting-Wen Yang, Li-Na Sun, Ting Zhang, Yu-Rong Pan, Jun Li, Yang-Yang Li, Zhi-Yong Han, Wan-Bang Sun, Xin-Sheng Yao, Xiao-Yan He   +10 more
doaj   +1 more source