Results 81 to 90 of about 19,601 (224)

Number of amino acids in the CDR3 region.

, 2015
Percentages of BcR sequences of different lengths. A) Length distribution of heavy chain (HC), light chain (LC) κ and LCλ CDR3 sequences of all influenza NP-specific B cells.
Yamen Dwai (757120), Susanne Horn (231432), Sven Reiche (757119), Michael Sieg (757122), Christian Jassoy (267172), Bianca M. Bussmann (757121)   +5 more
core   +1 more source

CDR3 lengths for the heavy (A) and light chains (B) of the controls.

, 2022
Distribution of functional clone size was calculated as the average proportion of functional clones for each observed CDR3 length. CDR3 length is defined from position 105 to 117 without the conserved cysteine of FR3 nor the first tryptophan ...
Jolyon Martin (13020735), Steven G. Friedenberg (9553318), Albert J. Vilella (13020738), David Sargan (7063688), Allan Bradley (30345), Jonah N. Cullen (5394503), Amy Treeful (13020741)   +6 more
core   +1 more source

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Allergy, EarlyView.
Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T‐cell release of barrier‐repressing cytokines (IL‐4, IL‐13, IL‐22, OSM). Cytokine signalling drives JAK‐dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic‐mediated eradication of S. aureus induces
Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels Ødum   +23 more
wiley   +1 more source

Contribution of CDR3 in characterization of camelid VHH and its aflatoxin B1-binding interaction

Food Chemistry Advances
The single variable domain of heavy chain (VHH) antibodies, owing to their unique properties, has gained attention in immunoassays. However, compared with macromolecule antigens, in the case of small molecule haptens, such as aflatoxin B1 (AFB1), the ...
Hina Mukhtar, Lan Ma, Qian Pang, Xiaohong Wang, Jia Wang   +4 more
doaj   +1 more source

Cloning of Size-Selected Human Immunoglobulin Heavy-Chain Rearrangements from Third Complementarity-Determining Region Fingerprint Profiles

BioTechniques, 1996
Methods have been developed to rapidly visualize the size distribution of third complementarity-determining regions (CDR3) in immunoglobulin (Ig) and T-cell receptor (TCR) molecules.
Frank M. Raaphorst, Joseph Tami, Ignacio E. Sanz   +2 more
doaj   +1 more source

Purpose-Oriented Antibody Libraries Incorporating Tailored CDR3 Sequences [PDF]

Antibodies, 2015
The development of in vitro antibody selection technologies has allowed overcoming some limitations inherent to the hybridoma technology. In most cases, large repertoires of antibody genes have been assembled to create highly diversified libraries allowing the isolation of antibodies recognizing virtually any antigen. However, these universal libraries
Pauline Bonvin, Sophie Venet, Marie Kosco-Vilbois, Nicolas Fischer   +3 more
openaire   +2 more sources

TCR CDR3 spetratyping revealed predominance of a selected CDR3 length in expanded Vγ2Vδ2 T cells in kidney/liver tissue compartments in late local Mtb infection.

, 2013
Shown are the Vδ2 TCR CDR3 profiles revealed by Genescan-based spectratyping as previously described [22]. The numbers of nucleotides in the different CDR3 lengths were determined in control experiments [22], and were expressed as predicted numbers of ...
George Du (333842), Dan Huang (122168), Liyou Qiu (333838), Zheng W. Chen (122182), Richard Wang (84158), Yun Shen (333840), Keyuan Zhou (125498), Crystal Y. Chen (122165), Meihong Zhang (333837)   +8 more
core   +1 more source

Model prediction for full amino-acid sequence (CDR3+VJ) sharing in BCR repertoires.

, 2023
(A) Distribution of the sharing numberof CDR3 + V gene + J gene amino-acid sequences of the heavy chains of IgM repertoires from 10 individuals. Even though using this more stringent definition of sharing the number of public clonotypes remarkably ...
Aleksandra M. Walczak (7252508), Thierry Mora (369624), Natanael Spisak (12733857), María Ruiz Ortega (14676280)   +3 more
core   +1 more source

Systemic lupus erythematosus: molecular mimicry between anti-dsDNA CDR3 idiotype, microbial and self peptides as antigens for Th cells

Frontiers in Immunology, 2015
Systemic lupus erythematosus (SLE) is marked by a T helper (Th) cell dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A hallmark of SLE is the finding of IgG autoantibodies specific for dsDNA.
Kristin eAas-Hanssen, Keith M Thompson, Bjarne eBogen, Bjarne eBogen, Ludvig A Munthe   +4 more
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source