Results 51 to 60 of about 19,601 (224)
BMC Immunology, 2022 Background The B cell receptor (BCR) repertoire is highly diverse among individuals. Poor similarity of the spectrum among inbred baseline mice may limit the ability to discriminate true signals from those involving specific experimental factors.
Hongkai Wu +6 more
doaj +1 more source
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities [PDF]
Immunity, 2000 All rearranging antigen receptor genes have one or two highly diverse complementarity determining regions (CDRs) among the six that typically form the ligand binding surface. We report here that, in the case of antibodies, diversity at one of these regions, CDR3 of the V(H) domain, is sufficient to permit otherwise identical IgM molecules to ...
Xu, John L, Davis, Mark M
openaire +2 more sources
, 2012 Conserved CDR3 sequences from α chain of T cells exhibited a single peak on CDR3 spectratype analysis.
Qi Jin (12159) +10 more
core +1 more source
Evidence for Shaping of Light Chain Repertoire by Structural Selection
Frontiers in Immunology, 2018 The naïve immunoglobulin (IG) repertoire in the blood differs from the direct output of the rearrangement process. These differences stem from selection that affects the germline gene usage and the junctional nucleotides.
Adar Toledano +5 more
doaj +1 more source
Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening
Advanced Science, EarlyView.Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun +6 more
wiley +1 more source
Mutagenic oligonucleotides used to diversify the CDR3.
, 2019 The oligonucleotides T1-MUT-F, T20-MUT-F and TN16-MUT-F were used with framework T1, T20 and TN16 respectively. With the exception of the cysteine-encoding codons (enclosed in blue), all of the other codons at CDR3 encode NNK.
Alexandra Rucavado (32147) +5 more
core +1 more source
Restricted TcR β chain CDR3 clonotype is associated with resolved acute hepatitis B subjects
BMC Infectious Diseases, 2021 Background T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive.
Dangsheng Xiao +6 more
doaj +1 more source
Advanced Science, EarlyView.Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang +8 more
wiley +1 more source
Shared unique CDR3 amino acid sequences.
, 2019 Shared unique CDR3 amino acid sequences.
Bailey A. Bye (4752828) +6 more
core +1 more source
Folia VeterinariaNeuroinfections are difficult and time-consuming to treat. The main bottleneck in therapy is drugs’ inability to enter the central nervous system (CNS) via the blood-brain barrier (BBB).
Talpašová Lea +3 more
doaj +1 more source