Results 31 to 40 of about 19,601 (224)

Three most common CDR3 sequences by chain.

, 2022
Three most common CDR3 sequences by chain.
Jolyon Martin (13020735), Steven G. Friedenberg (9553318), Albert J. Vilella (13020738), David Sargan (7063688), Allan Bradley (30345), Jonah N. Cullen (5394503), Amy Treeful (13020741)   +6 more
core   +1 more source

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity

Frontiers in Oncology, 2022
Classification of patients with chronic lymphocytic leukemia (CLL) based on the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene has established predictive and prognostic relevance. The SHM status is assessed
Electra Sofou, Electra Sofou, Laura Zaragoza-Infante, Nikolaos Pechlivanis, Georgios Karakatsoulis, Sofia Notopoulou, Niki Stavroyianni, Fotis Psomopoulos, Elisavet Georgiou, Anne Langlois de Septenville, Frederic Davi, Andreas Agathangelidis, Anastasia Chatzidimitriou, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Kostas Stamatopoulos   +15 more
doaj   +1 more source

Functional Antibody CDR3 Fusion Proteins with Enhanced Pharmacological Properties [PDF]

Angewandte Chemie International Edition, 2013
Most mammalian antibodies have complementarity determining region (CDR) loops of 8–16 residues, while some human antibodies have longer, protruding CDR loops that play a role in virus neutralization.[1] The bovine antibody repertoire features a subgroup of antibodies with exceptionally long heavy chain complementarity determining region 3 (CDR3H) loops.
Yong, Zhang, Danling, Wang, Lorenzo, de Lichtervelde, Sophie B, Sun, Vaughn V, Smider, Peter G, Schultz, Feng, Wang   +6 more
openaire   +2 more sources

The impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients

OncoImmunology, 2019
Patients with metastatic melanoma were treated with tremelimumab and interferon-α (IFN) in a previously reported clinical trial [NCT00610857]. Responses were assessed by RECIST criteria as complete (CR) or partial (PR), stable disease (SD) or progressive
Arjun Khunger, Julie A. Rytlewski, Paul Fields, Erik C. Yusko, Ahmad A. Tarhini   +4 more
doaj   +1 more source

Comparison of T-cell receptor β chain variable region 23-1 open reading frame and 3-1 F CDR3 repertoire in cDNA and gDNA from peripheral blood mononuclear cells of healthy volunteers by high-throughput sequencing

Central European Journal of Immunology, 2018
The TRBV germline gene can be classified into three types: open reading frame (ORF), functional gene (F), and pseudogene (P); however, the differences and connections among ORF, functional gene, and pseudogene rearrangements and expression ...
Xiaoyan He, Bin Shi, Long Ma, Rui Ma, Aihua Peng, Suhong Sun, Xinsheng Yao   +6 more
doaj   +1 more source

The composition and variation of the BCR CDR3s in gastric cancer

Oncology Letters, 2018
Gastric cancer (GC) is the fourth most common type of cancer and the second most common cause of cancer-associated mortality worldwide. B cell-associated autoantibodies against tumor-associated antigens are attractive biomarkers for the development of noninvasive serological tests for the early detection of cancer.
Liu, Song, Zhu, Ying, Lin, Lie-Wen, Ding, Shun-Kai, Lin, Xiao-Cong, Zhong, Ke-Li, Pan, Kai, Dai, Yong   +7 more
openaire   +3 more sources

Affinity transfer to a human protein by CDR3 grafting of camelid VHH [PDF]

Protein Science, 2011
AbstractVHH is the binding domain of the IgG heavy chain. Some VHHs have an extremely long CDR3 that contributes to antigen binding. We studied the antigen binding ability of CDR3 by grafting a CDR3 from an antigen‐binding VHH onto a nonbinding VHH. cAb‐CA05‐(1RI8), the CDR3‐grafted VHH, had an antigen‐binding ability.
Hidetoshi, Inoue, Akiko, Iihara, Hideo, Takahashi, Ichio, Shimada, Isao, Ishida, Yoshitake, Maeda   +5 more
openaire   +2 more sources

Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire

Molecular Therapy, 2022
B cells have been engineered ex vivo to express an HIV-1 broadly neutralizing antibody (bNAb). B cell reprograming may be scientifically and therapeutically useful, but current approaches limit B cell repertoire diversity and disrupt the organization of the heavy-chain locus.
Tianling Ou, Wenhui He, Brian D. Quinlan, Yan Guo, Mai H. Tran, Pabalu Karunadharma, Hajeung Park, Meredith E. Davis-Gardner, Yiming Yin, Xia Zhang, Haimin Wang, Guocai Zhong, Michael Farzan   +12 more
openaire   +2 more sources

CDR3 properties by chain.

, 2022
Reported properties at each CDR3 position, including hydropathy, size, chemical class, charge, hydrogen donor or acceptor class, and polarity were calculated based upon the proportion of amino acids at each position averaged across included samples using
Jolyon Martin (13020735), Steven G. Friedenberg (9553318), Albert J. Vilella (13020738), David Sargan (7063688), Allan Bradley (30345), Jonah N. Cullen (5394503), Amy Treeful (13020741)   +6 more
core   +1 more source

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data

Communications Biology, 2021
Montemurro et al. present NetTCR-2.0, a convolutional neural network-based tool for predicting the interactions between T cell receptors and MHC-peptide complexes.
Alessandro Montemurro, Viktoria Schuster, Helle Rus Povlsen, Amalie Kai Bentzen, Vanessa Jurtz, William D. Chronister, Austin Crinklaw, Sine R. Hadrup, Ole Winther, Bjoern Peters, Leon Eyrich Jessen, Morten Nielsen   +11 more
doaj   +1 more source