Results 11 to 20 of about 19,601 (224)

Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorothioate-modified oligonucleotides backbone [PDF]

Frontiers in Immunology
IntroductionThe development of recombinant antibody binders against phosphorothioate-modified antisense oligonucleotides (PS-ASOs) remains challenging due to the highly polyanionic character and structural flexibility of the phosphorothioate backbone ...
Riccardo Galasso, Riccardo Galasso, Francesco Coppolino, Alessia Berbiglia, Alessia Berbiglia, Grete Francesca Privitera, Agata Famà, Giuseppe Valerio De Gaetano, Germana Lentini, Concetta Beninati, Concetta Beninati   +10 more
doaj   +2 more sources

A Phase II Trial of Perioperative Camrelizumab Plus Neoadjuvant Chemotherapy in Resectable Stage IIB-IIIB Lung Squamous Cell Carcinoma. [PDF]

MedComm (2020)
This phase II trial suggests the potential of perioperative camrelizumab plus neoadjuvant chemotherapy in patients with resectable stage IIB‐IIIB lung squamous cell carcinoma. The major pathological response rate (primary endpoint) was 60.0%, and the pathological complete response (pCR) rate was 44.4%.
Hu M, Liu S, Han Y, Wang F, Liu Y, Lu B, Li H, Gao Y, Wang Y, Yang W, Shi K, Xiao B, Wang Q, Du J, Lin H, Li X, Wang C, Zhang T.   +17 more
europepmc   +2 more sources

TCR-α CDR3 Loop Audition Regulates Positive Selection [PDF]

The Journal of Immunology, 2006
Abstract How positive selection molds the T cell repertoire has been difficult to examine. In this study, we use TCR-β-transgenic mice in which MHC shapes TCR-α use. Differential AV segment use is directly related to the constraints placed on the composition of the CDR3 loops. Where these constraints are low, efficient selection of αβ
Ferreira, Cristina, Furmanski, Anna L., Millrain, Maggie M., Bartok, Istvan, Guillaume, Philippe, Lees, Rosemary, Simpson, Elizabeth, MacDonald, H. Robson, Dyson, Julian   +8 more
openaire   +4 more sources

Study of the T-cell receptor repertoire by CDR3 spectratyping

Journal of Immunological Methods, 2017
The T-cell receptor (TCR) is the key player within the so called immunological synapse and the analysis of its repertoire offers a picture of both versatility and wideness of the whole immune T-cell compartment. Among the different approaches applied to its study the so-called spectratyping identifies the pattern of the third complementarity ...
Claudio Fozza, Francesca Barraqueddu, Giovanna Corda, Salvatore Contini, Patrizia Virdis, Fausto Dore, Silvana Bonfigli, Maurizio Longinotti   +7 more
openaire   +4 more sources

Alterations in BCR heavy chain CDR3 repertoire characteristics in pediatric mycoplasma pneumoniae infection [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionMycoplasma pneumoniae (MP) infection is a leading cause of pediatric pneumonia, triggering a complex immune response in which B cells play a critical role.
Yanfei Chen, Yi Yuan, Xingzhu Liu, Bin Li, Lijuan Meng, Ying Xiao, Zhongjian Su, Linfei Han, Hong Li, Lili Deng, Jun Li, Caixia Ye, Xing Zhang   +12 more
doaj   +2 more sources

The characteristics of TCR CDR3 repertoire in COVID-19 patients and SARS-CoV-2 vaccine recipients

Virulence
The COVID-19 pandemic and large-scale administration of multiple SARS-CoV-2 vaccines have attracted global attention to the short-term and long-term effects on the human immune system. An analysis of the “traces” left by the body’s T-cell immune response
Dewei Zhou, Yan Luo, Qingqing Ma, Yuanyuan Xu, Xinsheng Yao   +4 more
doaj   +2 more sources

T cell receptor CDR3 loops influence αβ pairing☆

Molecular Immunology, 2010
T cell receptor transfer is an attractive strategy for the generation of antigen specific T cells to target infection and malignancy. Cross pairing of the transduced and endogenous TCR chains produces new and potentially auto-reactive specificities and dilutes the therapeutic TCR.
Istvan Bartok, Stephen J. Holland, Helmut W. Kessels, Jonathan D. Silk, Mooza Alkhinji, Julian Dyson   +5 more
openaire   +2 more sources

An Antibody CDR3-Erythropoietin Fusion Protein [PDF]

ACS Chemical Biology, 2013
X-ray crystallographic analysis of a bovine antibody (BLV1H12) revealed a unique scaffold in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds into a solvent exposed, antiparallel β-stranded "stalk" fused with a disulfide cross-linked "knob" domain.
Yong, Zhang, Danling, Wang, Gus, Welzel, Ying, Wang, Peter G, Schultz, Feng, Wang   +5 more
openaire   +2 more sources

Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities

Cell Systems, 2023
Antigen-specific T cell receptor (TCR) sequences can have prognostic, predictive, and therapeutic value, but decoding the specificity of TCR recognition remains challenging. Unlike DNA strands that base pair, TCRs bind to their targets with different orientations and different lengths, which complicates comparisons.
Alexander M. Xu, William Chour, Diana C. DeLucia, Yapeng Su, Ana Jimena Pavlovitch-Bedzyk, Rachel Ng, Yusuf Rasheed, Mark M. Davis, John K. Lee, James R. Heath   +9 more
openaire   +3 more sources

T Cell Receptor Beta-Chain Profiling of Tumor Tissue, Peripheral Blood and Regional Lymph Nodes From Patients With Papillary Thyroid Carcinoma

Frontiers in Immunology, 2021
Objective: To study the characteristics of the T cell receptor (TCR) repertoire in cancer tissue, peripheral blood and regional lymph nodes (LNs) from patients with papillary thyroid carcinoma (PTC).Methods: PTC tissue, peripheral blood mononuclear cells
Yizeng Wang, Yuanchao Liu, Li Chen, Zuoyu Chen, Xiaoning Wang, Ruoyu Jiang, Ke Zhao, Xianghui He   +7 more
doaj   +1 more source