Results 101 to 110 of about 34,505 (262)
T-Cell activation: a queuing theory analysis at low agonist density [PDF]
, 2006 We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R. +3 more
core +1 more source
Allergy, EarlyView.ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche +11 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing
Cellular Physiology and Biochemistry, 2016 Background/Aims: To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast array of T-cell receptors, collectively referred to as the TCR repertoire.
Xianliang Hou +8 more
doaj +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Influence of age and HLA-haplotype on TCR-VB-repertoire and lymphocyte subtypes in peripheral blood
, 2011 Diese Arbeit befasste sich mit flusszytometrischen Analysen von peripherem Blut gesunder Probanden. Entzündliche-, Autoimmun-, oder Tumorerkrankungen verän-dern das TCR-VB-Repertoire von gesunden Menschen.
Gaber, Rami (139379959)
core +1 more source
, 2022 Advances in next-generation sequencing (NGS) have improved the resolution of T-cell receptor (TCR) repertoire analysis, and recent single-cell sequencing has made it possible to obtain information about TCR pairs.
Cheol-Hwa Hong (14137689) +3 more
core +1 more source
T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma
Cancer Science, EarlyView.T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng +11 more
wiley +1 more source
Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires
Frontiers in Immunology, 2019 High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets.
Sofie Gielis +20 more
doaj +1 more source
, 2022 Advances in next-generation sequencing (NGS) have improved the resolution of T-cell receptor (TCR) repertoire analysis, and recent single-cell sequencing has made it possible to obtain information about TCR pairs.
Cheol-Hwa Hong (14137689) +3 more
core +1 more source