Results 121 to 130 of about 34,505 (262)

A novel adaptor protein, ARAP, orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF‐κB‐mediated cytokine production

Immunology &Cell Biology, EarlyView.
ARAP selectively regulates FcγR‐mediated signaling in dendritic cells. Loss of ARAP impairs phosphorylation of key signaling proteins, Rap1 activation, and integrin‐mediated adhesion, as well as NF‐κB p65 nuclear translocation and downstream cytokine production.
Chohee Park, Mi Jin Yu, Jong Ran Lee
wiley   +1 more source

Neutral and selective drivers of TCR repertoire diversity

The vertebrate adaptive immune system relies on the immense diversity of T cell receptors (TCRs) and immunoglobulins (IGs) to recognize a wide array of pathogens.
Yiu, Hao Hong
core   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells.

, 2017
To analyze the potential role of Tregs in controlling the TCR repertoire breadth to a non-self-antigen, a TCRβ transgenic mouse model (EF4.1) expressing a limited, yet polyclonal naïve T-cell repertoire was used.
Fontaine, Martina, Leo, Oberdan, Isabel Vogel, Vogel, Isabel, George Kassiotis, Oberdan Leo, Yves‐Rémi Van Eycke, Galuppo, Adrien, Ajouaou, Yousra, Kassiotis, George, Yousra Ajouaou, Van Eycke, Yves-Remi, Christine Decaestecker, Adrien Galuppo, Muriel Moser, Decaestecker, Christine, Martina Fontaine, Moser, Muriel   +17 more
core   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy

Purpose: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non-small cell lung cancer (NSCLC). Experimental Design: In this study, next-
Nadal, Ernest, Provencio, Mariano, Viñolas, Nuria, Parra, Edwin R., Cruz-Bermúdez, Alberto, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, Calvo, Virginia, Romero, Atocha, Bernabé Caro, Reyes, Lázaro, Martín, Wistuba, Ignacio I., Barquín, Miguel, Rocha, Pedro, López-Vivanco, Guillermo, Barneto Aranda, Isidoro, Dómine, Manuel, Massuti, Bartomeu, Del Barco, Edel, García Campelo, María del Rosario, de Castro-Carpeño, Javier, Viteri, Santiago, Sierra-Rodero, Belén, Cobo, Manuel, Kadara, Humam, Sanchez-Espiridion, Beatriz, Casarrubios, Marta, Laza-Briviesca, Raquel, Insa, Amelia   +29 more
core  

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source