Results 141 to 150 of about 206,427 (253)

Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells.

, 2017
To analyze the potential role of Tregs in controlling the TCR repertoire breadth to a non-self-antigen, a TCRβ transgenic mouse model (EF4.1) expressing a limited, yet polyclonal naïve T-cell repertoire was used.
Fontaine, Martina, Leo, Oberdan, Isabel Vogel, Vogel, Isabel, George Kassiotis, Oberdan Leo, Yves‐Rémi Van Eycke, Galuppo, Adrien, Ajouaou, Yousra, Kassiotis, George, Yousra Ajouaou, Van Eycke, Yves-Remi, Christine Decaestecker, Adrien Galuppo, Muriel Moser, Decaestecker, Christine, Martina Fontaine, Moser, Muriel   +17 more
core   +1 more source

Unraveling the chicken T cell repertoire with enhanced genome annotation

Frontiers in Immunology
T cell receptor (TCR) repertoire sequencing has emerged as a powerful tool for understanding the diversity and functionality of T cells within the host immune system.
Simon P. Früh, Simon P. Früh, Martin A. Früh, Benedikt B. Kaufer, Thomas W. Göbel   +4 more
doaj   +1 more source

Designing and Maintaining the Mature TCR Repertoire [PDF]

Immunity, 1999
Viret, Christophe, Wong, F.Susan, Janeway Jr., Charles A   +2 more
openaire   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Bulk T-cell receptor sequencing confirms clonality in obstetric antiphospholipid syndrome and may as a potential biomarker

Autoimmunity
The heterogeneity of the T cell receptor (TCR) repertoire critically influences the autoimmune response in obstetric antiphospholipid syndrome (OAPS) and is intimately associated with the prophylaxis of autoimmune disorders.
Qi Liu, Shuo Yang, Yuan Tan, Weimin Feng, Qingchen Wang, Jiao Qiao, Boxing Yang, Chong Wang, Jingjin Tao, He Wang, Liyan Cui   +10 more
doaj   +1 more source

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, EarlyView.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

CD8⁺ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex

, 2013
CD8⁺ T cells recognize infected or dysregulated cells via the clonotypically expressed αβ TCR, which engages Ag in the form of peptide bound to MHC class I (MHC I) on the target cell surface. Previous studies have indicated that a diverse Ag-specific TCR
Koning, Dan, Koning, D., Ladell, Kristin Ingrid, Kesmir, C., Miles, John J., Kesmir, Can, Venturi, V., Costa, Ana I., Borghans, Jose A.M., Venturi, Vanessa, Costa, A. I., Miles, John James, Hoof, Ilka, Schellens, Ingrid M.M., Hoof, I., Nanlohy, N. M., Borghans, J. A. M., van Baarle, D., Ladell, Kristin, Price, David, Matthews, Katherine K., van Baarle, Debbie, Nanlohy, Nening M., Schellens, I. M. M., Price, David A.   +24 more
core   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

C082 | T-CELL RECEPTOR-VΒ REPERTOIRE FLOW CYTOMETRY ANALYSIS SHOWED ABSOLUTE CONCORDANCE WITH MOLECULAR ANALYSIS OF TCR GENE REARRANGEMENT IN THE DIAGNOSIS OF T-CELL LYMPHOPROLIFERATIVE DISORDER: OBSERVATIONAL STUDY FROM A SINGLE CENTER EXPERIENCE.

Haematologica
Background: Clonality assessment is critical to differentiate between reactive and pathological T- cell lymphocytosis, and it usually relies on molecular analysis of T-Cell Receptor (TCR) gene rearrangement, which is considered the gold standard assay ...
M. Antonacci, J. Micozzi, A. Costa, A. Laganà, M.L. Milani, S. Intoppa, V. Bellomarino, M.G. Nardacci, M. Biglietto, S. Imperatore, M.L. Bisegna, M. Martelli, I. Della Starza, M.S. De Propris   +13 more
doaj