Results 141 to 150 of about 58,781 (291)

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Predominant utilization of V beta 8+ T cell receptor genes in the H-2Ld- restricted cytotoxic T cell response against the immediate-early protein pp89 of the murine cytomegalovirus [PDF]

, 1989
Cytotoxic T cell responses to the murine Cytomegalovirus (MCMV) were elicited in BALB/c mice (H-2d) by infectious virus. Eight days after infection, MCMV-primed local lymph node T cells were either depleted for T cells expressing a V beta 8+ TCR or ...
Eichmann, K., Koszinowski, Ulrich H., Melchers, I., Roedewald, H. R.   +3 more
core  

Ultrafast TCR clustering and accurate repertoire classification using isometric transformation

, 2020
Bo Li
openalex   +1 more source

Oligoclonality of Rat Intestinal Intraepithelial T Lymphocytes: Overlapping TCR β-Chain Repertoires in the CD4 Single-Positive and CD4/CD8 Double-Positive Subsets [PDF]

, 1999
Lars Helgeland, Finn–Eirik Johansen, Jon O. Utgaard, John Torgils Vaage, Per Brandtzæg   +4 more
openalex   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

TCRpred: incorporating T-cell receptor repertoire for clinical outcome prediction

Frontiers in Genetics
T-cell receptor (TCR) plays critical roles in recognizing antigen peptides and mediating adaptive immune response against disease. High-throughput technologies have enabled the sequencing of TCR repertoire at the single nucleotide level, allowing ...
Meiling Liu, Yang Liu, Li Hsu, Qianchuan He   +3 more
doaj   +1 more source

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells [PDF]

, 2017
Nils-Petter Rudqvist, Karsten A. Pilones, Claire Lhuillier, Erik Wennerberg, John-William Sidhom, Ryan Emerson, Harlan Robins, Jonathan P. Schneck, Silvia C. Formenti, Sandra Demaria   +9 more
openalex   +1 more source

Supplementary Fig. S1-S5 from TCR Repertoire Diversity of Peripheral PD-1⁺CD8⁺ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer [PDF]

, 2023
Jiefei Han, Jianchun Duan, Hua Bai, Yuqi Wang, Rui Wan, Xin Wang, Si Chen, Yanhua Tian, Di Wang, Kailun Fei, Zhuoran Yao, Shuhang Wang, Zhimin Lu, Zhijie Wang, Jie Wang   +14 more
openalex   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source