Results 151 to 160 of about 34,505 (262)

Unraveling the chicken T cell repertoire with enhanced genome annotation

Frontiers in Immunology
T cell receptor (TCR) repertoire sequencing has emerged as a powerful tool for understanding the diversity and functionality of T cells within the host immune system.
Simon P. Früh, Simon P. Früh, Martin A. Früh, Benedikt B. Kaufer, Thomas W. Göbel   +4 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

C082 | T-CELL RECEPTOR-VΒ REPERTOIRE FLOW CYTOMETRY ANALYSIS SHOWED ABSOLUTE CONCORDANCE WITH MOLECULAR ANALYSIS OF TCR GENE REARRANGEMENT IN THE DIAGNOSIS OF T-CELL LYMPHOPROLIFERATIVE DISORDER: OBSERVATIONAL STUDY FROM A SINGLE CENTER EXPERIENCE.

Haematologica
Background: Clonality assessment is critical to differentiate between reactive and pathological T- cell lymphocytosis, and it usually relies on molecular analysis of T-Cell Receptor (TCR) gene rearrangement, which is considered the gold standard assay ...
M. Antonacci, J. Micozzi, A. Costa, A. Laganà, M.L. Milani, S. Intoppa, V. Bellomarino, M.G. Nardacci, M. Biglietto, S. Imperatore, M.L. Bisegna, M. Martelli, I. Della Starza, M.S. De Propris   +13 more
doaj  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

An innovative and affordable quantitative assessment of human TCR repertoire [PDF]

EBioMedicine, 2020
Roberta Amoriello, Clara Ballerini
openaire   +3 more sources

TCR Repertoire Analysis During Therapeutic Interventions in Liver Diseases Using Next-Generation Sequencing [PDF]

Background and Aim The T cell receptor (TCR) can recognize a vast number of antigens and is closely associated with the pathogenesis of various diseases including autoimmune diseases and malignancies.
村岡, 優, 鈴木, 雄一朗, Enomoto, Nobuyuki, タカダ, ヒトミ, 24599, Takada, Hitomi, 23400, Sato, Mitsuaki, 23566, 24216, マエカワ, シンヤ, Suzuki, Yuichiro, コミヤマ, ヤスユキ, 23282, 佐藤, 光明, 80377506, 24770, 高野, 伸一, ムラオカ, マサル, Maekawa, Shinya, Muraoka, Masaru, Nakakuki, Natsuko, 大澤, 玲於奈, 小宮山, 泰之, 24703, Osawa, Leona, 榎本, 信幸, タカノ, シンイチ, Komiyama, Yasuyuki, 24720, サトウ, ミツアキ, 前川, 伸哉, 20596887, エノモト, ノブユキ, スズキ, ユウイチロウ, 70397298, Takano, Shinichi, 20251530, 高田, ひとみ, オオサワ, レオナ, 13479   +40 more
core  

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source