Results 131 to 140 of about 34,505 (262)

TCRpred: incorporating T-cell receptor repertoire for clinical outcome prediction

Frontiers in Genetics
T-cell receptor (TCR) plays critical roles in recognizing antigen peptides and mediating adaptive immune response against disease. High-throughput technologies have enabled the sequencing of TCR repertoire at the single nucleotide level, allowing ...
Meiling Liu, Yang Liu, Li Hsu, Qianchuan He   +3 more
doaj   +1 more source

CD8⁺ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex

, 2013
CD8⁺ T cells recognize infected or dysregulated cells via the clonotypically expressed αβ TCR, which engages Ag in the form of peptide bound to MHC class I (MHC I) on the target cell surface. Previous studies have indicated that a diverse Ag-specific TCR
Koning, Dan, Koning, D., Ladell, Kristin Ingrid, Kesmir, C., Miles, John J., Kesmir, Can, Venturi, V., Costa, Ana I., Borghans, Jose A.M., Venturi, Vanessa, Costa, A. I., Miles, John James, Hoof, Ilka, Schellens, Ingrid M.M., Hoof, I., Nanlohy, N. M., Borghans, J. A. M., van Baarle, D., Ladell, Kristin, Price, David, Matthews, Katherine K., van Baarle, Debbie, Nanlohy, Nening M., Schellens, I. M. M., Price, David A.   +24 more
core   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

A Phase II Trial of Perioperative Camrelizumab Plus Neoadjuvant Chemotherapy in Resectable Stage IIB–IIIB Lung Squamous Cell Carcinoma

MedComm, Volume 7, Issue 7, July 2026.
This phase II trial suggests the potential of perioperative camrelizumab plus neoadjuvant chemotherapy in patients with resectable stage IIB‐IIIB lung squamous cell carcinoma. The major pathological response rate (primary endpoint) was 60.0%, and the pathological complete response (pCR) rate was 44.4%.
Mingming Hu, Shuku Liu, Yi Han, Feng Wang, Yang Liu, Baohua Lu, Hongxia Li, Yuan Gao, Ying Wang, Wei Yang, Kang Shi, Bo Xiao, Qunhui Wang, Juan Du, Haifeng Lin, Xiaomi Li, Chong Wang, Tongmei Zhang   +17 more
wiley   +1 more source

Deciphering TCR repertoire diversity by RepSeq data modelinig

, 2016
Les lymphocytes T (LT) sont des acteurs-clés du système immunitaire, un système complexe et dynamique évoluant au cours de la vie de l'organisme. On appelle " répertoire lymphocytaire ", une collection de lymphocytes partageant un même phénotype, une ...
Chaara, Wahiba
core  

Cross‐Level Regulatory Interactions Underlying Human Immune Aging

MedComm, Volume 7, Issue 7, July 2026.
We performed multi‐omics sequencing on peripheral blood samples from 69 individuals aged 23–75 years and identified multi‐layered molecular interaction networks underlying the process of immune senescence, which provides a comprehensive multi‐omics framework for understanding immune aging and identifying potential strategies to delay immunosenescence ...
Quanyou Wu, Botao Zhang, Xiaochen Zhi, Qi Zhang, Kai Zhang, Yaru Wang, Kaitai Zhang, Lin Feng, Shujun Cheng, Ting Xiao   +9 more
wiley   +1 more source

Circulating T-cell receptor repertoire and clinicopathological correlations in breast cancer patients: immune repertoire analysis from the VGH-TAYLOR study

Breast Cancer Research
Sequencing of the T-cell receptor (TCR) repertoire can reflect immune status and monitor treatment responses. Here, we aimed to characterize the TCRβ repertoire and its correlation with clinical and prognostic significance in breast cancer.
Ling-Ming Tseng, Chi-Cheng Huang, Ji-Lin Chen, Yi-Fang Tsai, Ta-Chung Chao, Wen-Chi Wu, Pei-Ju Lien, Yen-Shu Lin, Chin-Jung Feng, Yen-Jen Chen, Jiun-I. Lai, Jen-Hwey Chiu, Chih-Yi Hsu, Chun-Yu Liu   +13 more
doaj   +1 more source

An Aging Clock Based on Immune Repertoire Features: COVID‐19 Accelerates Aging

Aging Cell, Volume 25, Issue 7, July 2026.
We systematically profiled TCR/BCR repertoires in Chinese individuals and paired COVID‐19 samples, revealed aging‐driven remodeling and COVID‐accelerated immune senescence, and built a reliable immune repertoire aging clock for immune senescence evaluation.
Xin Gao, Si‐Jia Li, Jin Li, Zi‐Hui Wang, Lv‐Tao Zeng, Ya‐Qing Ma, Ya‐Min Dang, Ying‐Min Zhang, Hong‐Lei Liu, Li‐Qun Zhang, Jing Pang, Ju Cui, Tie‐Mei Zhang, Jian‐Ping Cai   +13 more
wiley   +1 more source

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

, 2008
Why some virus-specific CD8 TCR repertoires are diverse and others restricted or "oligoclonal" has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence of T cell cross-reactivity.
Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Selin, Liisa K., Chen, Alex T., Welsh, Raymond M., Cornberg, Markus, Kim, Sung-Kwon, Celada, Franco, Wilkinson, Lee A., Brehm, Michael A.   +10 more
core   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source