Results 111 to 120 of about 206,427 (253)

Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires

Frontiers in Immunology, 2019
High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets.
Sofie Gielis, Sofie Gielis, Sofie Gielis, Pieter Moris, Pieter Moris, Wout Bittremieux, Wout Bittremieux, Wout Bittremieux, Nicolas De Neuter, Nicolas De Neuter, Nicolas De Neuter, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Kris Laukens, Kris Laukens, Kris Laukens, Pieter Meysman, Pieter Meysman, Pieter Meysman   +20 more
doaj   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

T cell receptor repertoire profiling predicts the prognosis of HBV‐associated hepatocellular carcinoma

Cancer Medicine, 2018
Tumor‐infiltrating T cell repertoire has been demonstrated to be closely associated with anti‐tumor immune response. However, the relationship between T cell repertoire in tumor tissue and prognosis has never been reported in Hepatocellular carcinoma ...
Kai‐Rong Lin, Fei‐Wen Deng, Ya‐Bin Jin, Xiang‐Ping Chen, Ying‐Ming Pan, Jin‐Huan Cui, Zhi‐Xuan You, Huan‐Wei Chen, Wei Luo   +8 more
doaj   +1 more source

TCR Repertoire as a Novel Indicator for Immune Monitoring and Prognosis Assessment of Patients With Cervical Cancer

Frontiers in Immunology, 2018
There is increasing evidence that deep sequencing-based T cell repertoire can sever as a biomarker of immune response in cancer patients; however, the characteristics of T cell repertoire including diversity and similarity, as well as its prognostic ...
Jin-Huan Cui, Kai-Rong Lin, Song-Hua Yuan, Ya-Bin Jin, Xiang-Ping Chen, Xi-Kang Su, Jun Jiang, Ying-Ming Pan, Shao-Long Mao, Xiao-Fan Mao, Wei Luo   +10 more
doaj   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Influence of age and HLA-haplotype on TCR-VB-repertoire and lymphocyte subtypes in peripheral blood

, 2011
Diese Arbeit befasste sich mit flusszytometrischen Analysen von peripherem Blut gesunder Probanden. Entzündliche-, Autoimmun-, oder Tumorerkrankungen verän-dern das TCR-VB-Repertoire von gesunden Menschen.
Gaber, Rami (139379959)
core   +1 more source

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

eLife, 2018
The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire sequencing data has the potential to decode disease associations from large cohorts with ...
William S DeWitt III, Anajane Smith, Gary Schoch, John A Hansen, Frederick A Matsen IV, Philip Bradley   +5 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source