Results 161 to 170 of about 58,781 (291)

Factors affecting TCR-repertoire diversity

Immunology Today, 1994
Wedderburn, L, Bowness, P
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, Volume 600, Issue 9, Page 1265-1287, May 2026.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Distorted TCR repertoires define multisystem inflammatory syndrome in children

, 2022
Amna Malik, Eszter Tóth, Michelle S. Teng, Jacob Hurst, Eleanor Watt, Lauren A. Wise, Natalie Kent, Jack Bartram, Louis Grandjean, Margarita Dominguez‐Villar, Stuart Adams, Nichola Cooper   +11 more
openalex   +2 more sources

Designing and Maintaining the Mature TCR Repertoire [PDF]

Immunity, 1999
Viret, Christophe, Wong, F.Susan, Janeway Jr., Charles A   +2 more
openaire   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

ImmunTraCkeR® as a reliable TCR repertoire profiling tool to understand immune response and to explore immunotherapy biomarkers [PDF]

, 2013
Isabelle Tanneau, Audrey Nondé, Anaïs Courtier, Gilles Parmentier, Marlène Noël, Audrey Grivès, Solène Perez, Nadia Plantier, Jean-François Mouret, Orchidée Filipe‐Santos, Manuarii Manuel   +10 more
openalex   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Bulk T-cell receptor sequencing confirms clonality in obstetric antiphospholipid syndrome and may as a potential biomarker

Autoimmunity
The heterogeneity of the T cell receptor (TCR) repertoire critically influences the autoimmune response in obstetric antiphospholipid syndrome (OAPS) and is intimately associated with the prophylaxis of autoimmune disorders.
Qi Liu, Shuo Yang, Yuan Tan, Weimin Feng, Qingchen Wang, Jiao Qiao, Boxing Yang, Chong Wang, Jingjin Tao, He Wang, Liyan Cui   +10 more
doaj   +1 more source

Author response: Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

, 2019
Rebeca Jimeno, Marta Lebrusant‐Fernandez, Christian Margreitter, Beth Lucas, Natacha Veerapen, Gavin Kelly, Gurdyal S. Besra, Franca Fraternali, Jo Spencer, Graham Anderson, Patricia Barral   +10 more
openalex   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source