Characterization of bone marrow T cells in monoclonal gammopathy of undetermined significance, multiple myeloma, and plasma cell leukemia demonstrates increased infiltration by cytotoxic/Th1 T cells demonstrating a squed TCR‐Vβ repertoire [PDF]
, 2006 Martín Pérez‐Andrés +9 more
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An innovative and affordable quantitative assessment of human TCR repertoire [PDF]
EBioMedicine, 2020 Roberta Amoriello, Clara Ballerini
openaire +3 more sources
The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development
European Journal of Immunology, Volume 56, Issue 5, May 2026.YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze +7 more
wiley +1 more source
A Novel PTPN2 Isoform Differentially Regulates Immune Response
European Journal of Immunology, Volume 56, Issue 5, May 2026.The A allele of the intronic SNP rs80262450 in the PTPN2 gene favors the expression of the splicing isoform PTPN2.4. This cytoplasmic isoform enhances TNF‐α production in myeloid cells, thereby contributing to intestinal inflammation. These findings identify PTPN2.4 as a key pathogenic regulator and potential therapeutic target for inflammatory bowel ...
Xiaoguang Li +16 more
wiley +1 more source
Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia. [PDF]
Front Immunol, 2023 Pospiech M +6 more
europepmc +1 more source
European Journal of Immunology, Volume 56, Issue 5, May 2026.This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low‐grade inflammation in 5‐12‐year‐old CHD children who underwent early‐life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent‐like T cells.
Yusuf Eshimutu Abu +13 more
wiley +1 more source
TCR repertoire in CD4 T cells of type 1 diabetes patients and healthy donors
, 2019 Iria Gómez-Touriño +4 more
openalex +1 more source
Immune Tolerance Maintained by Cooperative Interactions between T Cells and Antigen Presenting Cells Shapes a Diverse TCR Repertoire [PDF]
, 2015 Katharine Best +2 more
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VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins
, 2021 Sebastian Fischer +2 more
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