Results 191 to 200 of about 34,505 (262)

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

The Journal of Pathology, Volume 269, Issue 2, Page 164-181, June 2026.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen, Satu Tiainen, Jouni Kujala, Linnea Muhonen, Ponnuswamy Mohanasundaram, Tuomas Tikkanen, Ina Pöhner, Tommi Patinen, Simone Adinolfi, Juha P Väyrynen, Päivi Auvinen, Arto Mannermaa, Petri Pölönen, Tuomas Rauramaa, Anna‐Liisa Levonen   +14 more
wiley   +1 more source

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage. [PDF]

Genes Genomics, 2022
Wang G, Wang Y, Jiang S, Fan W, Mo C, Gong W, Chen H, He D, Huang J, Ou M, Hou X.   +10 more
europepmc   +1 more source

SARS-CoV-2 epitope-specific T cells: Immunity response feature, TCR repertoire characteristics and cross-reactivity. [PDF]

Front Immunol, 2023
Yang G, Wang J, Sun P, Qin J, Yang X, Chen D, Zhang Y, Zhong N, Wang Z.   +8 more
europepmc   +1 more source

A new perspective on cancer treatment: the interaction and application prospect between ICIs and radiotherapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 184-191, June 2026.
The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song, Lei Wang, Guopeng Zhao, Song Tan, Xin Liu, Xinghua Li   +5 more
wiley   +1 more source

Pre-treatment peripheral blood TCR repertoire as a predictor of response in patients with NSCLC treated with immunochemotherapy. [PDF]

BMC Cancer
Yang Y, Jiang HY, Li Y, Wu F, Chen ZY, Zheng GP, Su WZ, Wang HL, Pang M.   +8 more
europepmc   +1 more source

Clonal Distribution and Intratumor Heterogeneity of the TCR Repertoire in Papillary Thyroid Cancer With or Without Coexistent Hashimoto's Thyroiditis. [PDF]

Front Immunol, 2022
Cui L, Zhang C, Ding H, Feng D, Huang H, Lu Z, Liu B.   +6 more
europepmc   +1 more source

Vascular Immune Remodeling: A CD4+ T Cell–Driven Immune Trajectory Associated With Arterial Stiffness

Aging Cell, Volume 25, Issue 6, June 2026.
This study integrated arterial stiffness with peripheral TCRβ repertoire and single‐cell transcriptomics in adults without cardiovascular disease, revealing a CD4+ T cell–driven “vascular immune remodeling” trajectory distinct from classical immunosenescence: increased TCR diversity, broad expansion of low‐frequency public clones and virus‐associated ...
Yu Miao, Bangwei Chen, Changqing Zeng, Xiaofen Wu, Minglei Yang, Cuntai Zhang, Jianguo Zhang, Yutao Du, Tao Li, Lei Ruan   +9 more
wiley   +1 more source

Peripheral blood TCR repertoire improves early detection across multiple cancer types utilizing a cancer predictor. [PDF]

Front Oncol
Tang Y, Liao X, Liao B, Peng D, Li Q.
europepmc   +1 more source

TCR repertoire and transcriptional signatures of circulating tumour-associated T cells facilitate effective non-invasive cancer detection. [PDF]

Clin Transl Med, 2022
Ji F, Chen L, Chen Z, Luo B, Wang Y, Lan X.   +5 more
europepmc   +1 more source

T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett, Ramatoulaye H. Ouattara, April L. Ferre   +2 more
wiley   +1 more source