Results 191 to 200 of about 58,781 (291)

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq. [PDF]

Sci Rep, 2023
Heimli M, Tennebø Flåm S, Sagsveen Hjorthaug H, Bjørnstad PM, Chernigovskaya M, Le QK, Tekpli X, Greiff V, Lie BA.   +8 more
europepmc   +1 more source

SOP for TCR repertoire

Evaluated and implemented SOPs. SOPs for TCR repertoire. Samples used for generating data to develop the tools and validate the software: melanoma, colorectal cancer, and ovarian cancer.
openaire   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients – PART 1: Risk Factors, Clinical Impact and Immune Response

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan, Emily Blyth, Gaurav Sutrave, Michelle K. Yong, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Lauren Stern   +7 more
wiley   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Perp deficiency promotes age‐related autoimmunity. ABSTRACT Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self‐tolerance. Numerous apoptosis‐related genes influence cell fate during T‐cell development.
Yan Zhou, Junrong Li, Xiao Leng, Jiao Shi, Gan Zhang, Shan Chen, Dong Liu, Qian Deng, Yan He, Guixiu Shi, Ying Xu, Yuan Liu, Yantang Wang   +12 more
wiley   +1 more source

TCR repertoire shaping of naïve T cell subsets in human ontogeny. [PDF]

Front Immunol
Myshkin MY, Leyn SA, Egorov ES, Shelyakin PV, Staroverov DB, Shagina IA, Kan NE, Lupyr KR, Barsova EV, Dzyubinskaya EV, Ventura-Carmenate Y, Tyutyunnik VL, Rebrikov DV, Chudakov DM, Britanova OV.   +14 more
europepmc   +1 more source

Unique features of the TCR repertoire of reactivated memory T cells in the experimental mouse tumor model. [PDF]

Comput Struct Biotechnol J, 2023
Kalinina A, Persiyantseva N, Britanova O, Lupyr K, Shagina I, Khromykh L, Kazansky D.   +6 more
europepmc   +1 more source

The thymic cortical epithelium determines the TCR repertoire of IL‐17‐producing γδT cells

, 2015
Takeshi Nitta, Ryunosuke Muro, Yukiko Shimizu, Sachiko Nitta, Hiroyo Oda, Yuki Ohte, Motohito Goto, Rieko Yanobu‐Takanashi, Tomoya Narita, Hiroshi Takayanagi, Hisataka Yasuda, Tadashi Okamura, Shigeo Murata, Harumi Suzuki   +13 more
openalex   +2 more sources

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source