Results 171 to 180 of about 34,505 (262)

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

TCR Repertoire Analysis Unveils the Link Between Kawasaki Disease and Viral Infection. [PDF]

Biomedicines
Geng Z, Zhou W, Fang Z, Jin Y, Qi G, Zhao L, Xie C, Wang Y, Gong F.   +8 more
europepmc   +1 more source

Unique features of the TCR repertoire of reactivated memory T cells in the experimental mouse tumor model. [PDF]

Comput Struct Biotechnol J, 2023
Kalinina A, Persiyantseva N, Britanova O, Lupyr K, Shagina I, Khromykh L, Kazansky D.   +6 more
europepmc   +1 more source

CRISPR/Cas9‐Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR‐Dependent and Independent CD8 T Cell Expansion

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Ex vivo characterization of antigen‐specific CD8 T cells is crucial but often limited by expansion bottlenecks. We identify p16INK4A as a key regulator of TCR‐dependent and homeostatic proliferation. CRISPR/Cas9 deletion of CDKN2A rescues proliferation and improves IFN‐γ secretion while maintaining TCR‐dependency, enabling robust expansion for ...
Silvia Fiori, Cecilia Adragna, Emilia Malvicini, Tommaso Basini, Donatella Galgano, Edoardo Scarpa, Sandra Jovic, Niklas A. Schmacke, Veit Hornung, Federica Sallusto, Ludovica Bruno, Antonio Lanzavecchia, Manuel Albanese   +12 more
wiley   +1 more source

Clonal reshaping and clinical outcomes after rechallenge in ICI-associated myocarditis: integrated single-cell and TCR repertoire analysis. [PDF]

J Immunother Cancer
Zhang J, He X, Zhang Y, Qian X, Song Y, Zhang S, Li Z, Wang Z, Lu B, Cai Q, Cheng L, Wang Y.   +11 more
europepmc   +1 more source

A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity. [PDF]

J Clin Immunol, 2023
Assing K, Jørgensen SE, Sandgaard KS, De Keukeleere K, B-Hansen M, Petersen MS, Hartling UB, Vaal TMK, Nielsen C, Jakobsen MA, Watt E, Adams S, Hao Q, Fagerberg C, Mogensen TH, Mogensen TH.   +15 more
europepmc   +1 more source

The Memory Inflation Response Against Spread‐Defective CMV Requires Priming‐Independent CD4+ T Cell Help

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Inducing memory inflation (MI) is a promising future vaccination strategy. We show that spread‐defective cytomegalovirus does not induce MI in the absence of CD4+ T cells. Support from CD4+ T cells can drive effector differentiation of MI cells, even late in the response, and contributes to long‐term response maintenance. ABSTRACT Memory inflation (MI)
Jack Barton, Yeonsu Kim, Matthias T. Warkotsch, Luka Cicin‐Sain, Mateusz P. Poltorak, Veit R. Buchholz, Dirk H. Busch   +6 more
wiley   +1 more source

TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing. [PDF]

Nat Methods
Pogorelyy MV, Kirk AM, Adhikari S, Minervina AA, Sundararaman B, Vegesana K, Brice DC, Scott ZB, SJTRC Study Team, Thomas PG.   +9 more
europepmc   +1 more source

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations. [PDF]

Front Immunol
Salnikova MA, Tuchynskaya KK, Minervina AA, Pogorelyy MV, Okhezin EV, Karganova GG, Mamedov IZ, Lebedev YB.   +7 more
europepmc   +1 more source

Spatiotemporal commonality of the TCR repertoire in a T-cell memory murine model and in metastatic human colorectal cancer. [PDF]

Cancer Immunol Immunother, 2023
Haraguchi M, Kiyotani K, Tate T, Sakata S, Sagawa R, Takagi S, Nagayama S, Takeuchi K, Takahashi K, Katayama R.   +9 more
europepmc   +1 more source