Results 1 to 10 of about 521,465 (311)

Innate Immunity and Neuroinflammation [PDF]

Mediators of Inflammation, 2013
Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful.
Abhishek Shastri, Domenico Marco Bonifati, Uday Kishore   +2 more
openaire   +6 more sources

Innate immunity [PDF]

Journal of Allergy and Clinical Immunology, 2010
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity ...
Stuart E, Turvey, David H, Broide
  +10 more sources

Foodies of Innate Immunity [PDF]

Journal of Innate Immunity, 2015
Heiko, Herwald, Arne, Egesten
openaire   +3 more sources

The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells [PDF]

, 2022
Aroylated phenylenediamines (APDs) are novel modulators of innate immunity with respect to enhancing the expression of antimicrobial peptides and maintaining epithelial barrier integrity.
Myszor, Iwona T., Agerberth, Birgitta, Sigurdsson, Snaevar, Myszor, IT, Eskelinen, E-L, Viktorsdottir, AR, Gudmundsson, GH, Agerberth, B,, Ogmundsdottir, MH, Gudmundsson, Gudmundur H., Ogmundsdottir, Margret Helga, Viktorsdottir, Alexia Ros, Eskelinen, Eeva-Liisa, Sigurdsson, S   +13 more
core   +2 more sources

Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection

Cell Death and Disease, 2023
Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin ...
Sarah Rosli, Christopher M. Harpur, Maggie Lam, Alison C. West, Christopher Hodges, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate   +7 more
doaj   +1 more source

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin   +16 more
doaj   +1 more source

Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation

Journal of Inflammation, 2023
Background Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce
Kristian Barry, Christopher Harpur, Maggie Lam, Michelle D. Tate, Ashley Mansell   +4 more
doaj   +1 more source

Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication

Nature Communications, 2022
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou   +11 more
doaj   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source