Results 31 to 40 of about 1,027,521 (307)

Targeting RIP Kinases in Chronic Inflammatory Disease

Biomolecules, 2021
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cell responses. Modes of extrinsic cell death, apoptosis and necroptosis, have now been shown to be potent drivers of deleterious inflammation, and mutations
Mary Speir, Tirta M. Djajawi, Stephanie A. Conos, Hazel Tye, Kate E. Lawlor   +4 more
doaj   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources

Western lifestyle linked to maladaptive trained immunity

eLife
Trained immunity (TI) refers to a state of innate immune cells that, after encountering an initial stimulus and undergoing epigenetic reprogramming and metabolic changes, allows them to respond more effectively to a subsequent challenge.
Aurelia Josephine Merbecks, Christabel Mennicken, Dennis Marinus de Graaf, Kateryna Shkarina, Theresa Wagner, Eicke Latz   +5 more
doaj   +1 more source

Innate immunity in tuberculosis: myths and truth.

, 2008
Tuberculosis is the most important bacterial infection world wide. The causative agent, Mycobacterium tuberculosis survives and proliferates within macrophages.
Korbel, Daniel S, Bianca E. Schneider, Ulrich E. Schaible, Schaible, Ulrich E, Daniel S. Korbel, Schneider, Bianca E   +5 more
core   +1 more source

Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

, 2020
Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation.
Irazoqui, Javier E
core   +1 more source

Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr^−/− Mice

Metabolites, 2020
Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach, Eicke Latz, Anette Christ   +2 more
doaj   +1 more source

Innate Immunity in Disease [PDF]

Clinical Gastroenterology and Hepatology, 2014
Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease.
David E, Elliott, Sana S, Siddique, Joel V, Weinstock   +2 more
openaire   +2 more sources

Expression of genes related to anti-inflammatory pathways are modified among farmers' children [PDF]

, 2014
The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in
Loeliger, Susanne, Roduit, Caroline; https://orcid.org/, van Hage, Marianne, Göran Pershagen, Sennhauser, Felix, Lauener, Roger P., Remo Frei, Marianne van Hage (91132), IRAS RATIA2, Felix Sennhauser, Susanne Loeliger (254440), von Mutius, Erika, Erika von Mutius (105805), Caroline Roduit (254441), Gert Doekes (397763), as part of the Parsifal study team,, Christian Bieli (531936), Waser, Marco, Cezmi A Akdis, Christian Bieli, Mutius, Erika von, Annika Scheynius, Roduit, Caroline, Riedler, Josef, Göran Pershagen (147977), LS IRAS EEPI GRA (Gezh.risico-analyse), Braun-Fahrländer, Charlotte, Remo Frei (254425), Roger P. Lauener (254451), Caroline Roduit, Akdis, Cezmi A, Risk Assessment of Toxic and Immunomodulatory Agents, Lauener, Roger P, Cezmi A. Akdis (187641), Akdis, Cezmi A., Marco Waser, Pershagen, Göran, Erika von Mutius, Doekes, Gert, Gert Doekes, Felix Sennhauser (531938), Josef Riedler, Susanne Loeliger, Charlotte Braun-Fahrländer, Hage, Marianne van, Frei, Remo, Scheynius, Annika, as part of the PARSIFAL study team, Roger P Lauener, Annika Scheynius (31954), Josef Riedler (194501), Charlotte Braun-Fahrländer (18248), Bieli, Christian, Marianne van Hage, Marco Waser (531937), Akdis Cezmi A., Pershagen, G,, Roduit C, Pershagen Göran, Loeliger Susanne, Scheynius A, Braun-Fahrländer C, Bieli Christian, van Hage Marianne, Waser, M, Sennhauser Felix, Frei R, Waser M, Frei Remo, Loeliger S, Pershagen G, Sennhauser F, Braun-Fahrländer Charlotte, Riedler, J, Riedler Josef, Loeliger, S, Lauener Roger P., Roduit Caroline, Bieli, C, von Mutius E, Scheynius, A,, Waser Marco, Doekes Gert, Riedler J, van, Hage M,, Frei, R, Akdis CA, Scheynius Annika, von Mutius Erika, Doekes, G, Bieli C, van Hage M, Doekes G, Roduit, C, Lauener RP   +94 more
core   +2 more sources

Signal transduction pathways that function in both development and innate immunity.

, 2010
C. elegans is developing in importance as a model for innate immunity. Several signaling pathways are known to be required for immune responses to a diverse range of pathogens, including the insulin signaling, p38 MAP kinase and transforming growth ...
Gravato-Nobre, M.J., Hodgkin, J., Partridge, F.A.   +2 more
core   +2 more sources

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source