Results 11 to 20 of about 524,193 (311)
Innate Immunity and Neuroinflammation [PDF]
Mediators of Inflammation, 2013 Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful.
Abhishek Shastri +2 more
openaire +7 more sources
Journal of Allergy and Clinical Immunology, 2010 Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity ...
Stuart E, Turvey, David H, Broide
+10 more sources
Foodies of Innate Immunity [PDF]
Journal of Innate Immunity, 2015 Heiko, Herwald, Arne, Egesten
openaire +4 more sources
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells [PDF]
, 2022 Aroylated phenylenediamines (APDs) are novel modulators of innate immunity with respect to enhancing the expression of antimicrobial peptides and maintaining epithelial barrier integrity.
Myszor, Iwona T. +13 more
core +4 more sources
Synthesis and validation of click-modified of NOD1/2 agonists [preprint] [PDF]
, 2023 This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.NOD1 and NOD2 sense small bacterial peptidoglycan fragments often called muropeptides.
Silverman, Neal +7 more
core +2 more sources
Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection
Cell Death and Disease, 2023 Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro-inflammatory form of cell death executed by the pore-forming protein gasdermin ...
Sarah Rosli +7 more
doaj +1 more source
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
EMBO Molecular Medicine, 2022 Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot +16 more
doaj +1 more source
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Journal of Inflammation, 2023 Background Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce
Kristian Barry +4 more
doaj +1 more source
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
doaj +1 more source
Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B [PDF]
, 2020 Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to
Michinori Kohara +4 more
core +1 more source