Results 11 to 20 of about 738,337 (299)

NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice

Nature Communications, 2023
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined,
L. S. Tran, L. Ying, K. D’Costa, G. Wray-McCann, G. Kerr, L. Le, C. C. Allison, J. Ferrand, H. Chaudhry, J. Emery, A. De Paoli, N. Colon, S. Creed, M. Kaparakis-Liaskos, J. Como, J. K. Dowling, P. A. Johanesen, T. A. Kufer, J. S. Pedersen, A. Mansell, D. J. Philpott, K. D. Elgass, H. E. Abud, U. Nachbur, B. A. Croker, S. L. Masters, R. L. Ferrero   +26 more
doaj   +1 more source

In vivo detection of lamellocytes in Drosophila melanogaster. [PDF]

, 2009
Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific ...
Brand, Braun, Carton, Evans, Evans, Goto, Hartenstein, Hoffmann, Hultmark, Konrad, Kurucz, Kurucz, Kurucz, Lanot, Metaxakis, Márkus, Márkus, Zettervall   +17 more
core   +1 more source

Verloren negatively regulates the expression of IMD pathway dependent antimicrobial peptides in Drosophila

Scientific Reports, 2021
Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection.
Pragya Prakash, Arghyashree Roychowdhury-Sinha, Akira Goto   +2 more
doaj   +1 more source

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

ATP-binding and hydrolysis of human NLRP3

Communications Biology, 2022
Analysis of the inflammasome-forming protein NLRP3 provides insights into the function of conserved residues in the ATP-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activation.
Rebecca Brinkschulte, David M. Fußhöller, Florian Hoss, Juan F. Rodríguez-Alcázar, Mario A. Lauterbach, Carl-Christian Kolbe, Melanie Rauen, Semra Ince, Christian Herrmann, Eicke Latz, Matthias Geyer   +10 more
doaj   +1 more source

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Breuer, Karin, Brinkman, Fiona S. L., Chen, Carol, Foroushani, Amir K., Hancock, Robert E.W., Laird, Matthew R, Lo, Raymond, Lynn, David J, Sribnaia, Anastasia, Winsor, Geoffrey L   +9 more
core   +1 more source

A functional DC cross talk promotes human ILC homeostasis in humanized mice

Blood Advances, 2017
: Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer.
Silvia Lopez-Lastra, Guillemette Masse-Ranson, Oriane Fiquet, Sylvie Darche, Nicolas Serafini, Yan Li, Mathilde Dusséaux, Helene Strick-Marchand, James P. Di Santo   +8 more
doaj   +1 more source

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Nature Communications, 2020
lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the ...
Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald   +7 more
doaj   +1 more source

Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders [PDF]

, 2006
Immunity is hypothesized to share limited resources with other physiological functions and may mediate life history trade-offs, for example between reproduction and survival.
Adamo, Archer, Berczi, Bourgeon, Bourgeon, Crippen, Criscuolo, Criscuolo, Daniel Ricquier, Demas, Demas, Demas, Elizalde, Eraud, Faggioni, François Criscuolo, Gross, Gullo, Guzik, Hamilton, Hangalapura, Hangalapura, Hanssen, Hanssen, Hanssen, Hanssen, Harvey, Hickman-Miller, Jarosinski, Keil, Korschgen, Lillehoj, Lord, Lourenco, Love, Lõhmus, Lõhmus, MacColl, MacDonald, Martin, Nilsson, Nordling, Norris, Ricart-Jané, Ricklefs, Rodriguez, Roitt, Råberg, Salman, Sheldon, Sophie Bourgeon, Svensson, Szabo, Thierry Raclot, Tieleman, Tosi, Verhulst, Viney, von Schantz, Wiersma, Yoccoz, Yvon Le Maho, Zuk   +62 more
core   +3 more sources

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +3 more sources