Results 1 to 10 of about 473,545 (264)

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

Mediators of Inflammation, 2019
Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with ...
Nuno Carvalho, André Barros, Hélder O. Coelho, Catarina F. Moita, Ana Neves-Costa, Dora Pedroso, Filipe C. Borges, Luís F. Moita, Paulo M. Costa   +8 more
doaj   +1 more source

Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin

Journal of Extracellular Vesicles
Nucleomodulins are a family of bacterial virulence proteins that traffic to the nucleus of host cells to disrupt nuclear processes and, in some cases, promote carcinogenesis.
Jack K. Emery, Variya Nemidkanam, Nina Colon, Kate R. J. Friesen, Lena H. M. Le, Angus R. Cramond, Maxine Yap, Mônica S. Barbosa, Georgie Wray‐McCann, David J. McGee, Natalia Castaño‐Rodríguez, Dongmei Tong, Caroline Skene, Laurent Terradot, Richard L. Ferrero   +14 more
doaj   +1 more source

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

Frontiers in Immunology
Lipopolysaccharide (LPS), also known as an endotoxin, is derived from Gram-negative bacteria. The intravenous administration of LPS induces an inflammatory response and causes systemic inflammation, such as cytokine storm.
Gen-Ichiro Soma, Gen-Ichiro Soma, Masataka Oda, Vindy Tjendana Tjhin, Chie Kohchi, Hiroyuki Inagawa, Hiroyuki Inagawa   +6 more
doaj   +1 more source

Encapsulation and Melanization Are Not Correlated to Successful Immune Defense Against Parasitoid Wasps in Drosophila melanogaster

Cells
Parasitoid elimination in Drosophila melanogaster involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a potential
Lilla B. Magyar, István Andó, Gyöngyi Cinege   +2 more
doaj   +1 more source

Molecular insights on the proangiogenic effects of VEGF like growth factor derived from horseshoe crab perivitelline fluid

Scientific Reports
The current study investigated the proangiogenic effects of fraction VII of perivitelline fluid (hscPVF-VEGF) obtained from the late-stage embryos of Indian horseshoe crab (Tachypleus gigas; Müller) using human umbilical cord tissue-derived MSCs (hUCMSCs)
K. G. Aghila Rani, Hrishikesh Pandit, Rambhadur Subedi, Sayli Otiv-Pandit, Anil Bankati Jogdand, Hajra Gupta, Prayagraj Fandilolu, Sushama Rokade, Susan Idicula-Thomas, Anil Chatterji, Taruna Madan   +10 more
doaj   +1 more source

Unlocking the potential for microbiome‐based therapeutics to address the sustainable development goal of good health and wellbeing

Microbial Biotechnology
Recent years have witnessed major advances and an ever‐growing list of healthcare applications for microbiome‐based therapeutics. However, these advances have disproportionately targeted diseases common in high‐income countries (HICs).
Emily L. Gulliver, Sara K. Di Simone, Michelle Chonwerawong, Samuel C. Forster   +3 more
doaj   +1 more source

Dissecting Cell Death Pathways in Influenza A Virus Infection: Comparative Insights from Human Models

Viruses
Influenza A virus remains a major global health threat, causing annual epidemics and occasional pandemics. Programmed cell death, including apoptosis, pyroptosis, and necroptosis, with emerging evidence for ferroptosis, plays a dual role in influenza ...
Ngoc Mai Khoi Nguyen, Alison C. West, Rebecca L. Ambrose, Michelle D. Tate   +3 more
doaj   +1 more source

A single entomopathogenic nematode infection assay for Drosophila melanogaster larvae

MethodsX
The entomopathogenic nematodes (EPNs) Steinernema carpocapsae and Steinernema hermaphroditum can efficiently infect the fruit fly, Drosophila melanogaster.
Sreeradha Mallick, Eric Kenney, Jacob Rashap, Ioannis Eleftherianos   +3 more
doaj   +1 more source

Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease

Scientific Reports
Mesenchymal stromal cells (MSCs) are multipotent adult stem cells which possess immunomodulatory and repair capabilities. In this study, we investigated whether MSC therapy could modulate inflammation and lung damage in the lungs of Scnn1b-transgenic ...
Declan F. Doherty, Lydia E. Roets, Caoifa M. Dougan, Ryan R. Brown, Ian J. Hawthorne, Cecilia O’Kane, Anna D. Krasnodembskaya, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon   +9 more
doaj   +1 more source

LSO-007 Trimeric oligonucleotides ameliorate disease in a mouse model of CLE-like inflammatory skin disease

Lupus Science and Medicine, 2023
Mary Speir, W Samantha N Jayasekara, Sunil Sapkota, Arwaf Alharbi, Olivier F Laczka, Michael P Gantier   +5 more
doaj   +1 more source