Results 41 to 50 of about 521,491 (212)
Nature CommunicationsInflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane.
Lisa D. J. Schiffelers +13 more
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Nature Communications, 2022 Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft +9 more
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mBio, 2023 Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells.
Xuqiu Lei +3 more
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Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection
Cell Death and DiseaseSevere influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli +9 more
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RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
Nature Communications, 2019 RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone +4 more
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Innate immunity and coagulation [PDF]
Journal of Thrombosis and Haemostasis, 2011 Infection frequently elicits a coagulation response. Endotoxin triggers the formation of tissue factor initiating coagulation, down regulates anticoagulant mechanisms including the protein C pathway and heparin-like proteoglycans and up regulates plasminogen activator inhibitor. The overall physiological result of this is to promote coagulation through
C T, Esmon, J, Xu, F, Lupu
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Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation
, 2020 Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation.
Irazoqui, Javier E
core +1 more source
Adaptive immunity in invertebrates: a straw house without a mechanistic foundation [PDF]
, 2007 Recently claims have been made for radical new insights in the field of invertebrate immunology that involve memory, specificity and/or maternal transfer of immunocompetence.
Smith, Valerie J., Hauton, Chris
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Mosquito Innate Immunity [PDF]
Insects, 2018 Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and the subsequent establishment of the pathogen within the mosquito.
Ankit Kumar +6 more
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Innate immunity to pathogens [PDF]
Current Opinion in Immunology, 2008 The innate immune system is responsible for early detection and response to pathogens that then modulate subsequent immune responses [1]. A characteristic of innate immunity is the recognition of pathogen associated molecular patterns (PAMPs) by germline-encoded receptors such as the Toll-like receptors (TLRs) [2].
Wayne M, Yokoyama, Marco, Colonna
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