Results 31 to 40 of about 738,107 (298)
Innate immune defects in HIV permissive cell lines. [PDF]
, 2016 Primary CD4+ T cells and cell lines differ in their permissiveness to HIV infection. Impaired innate immunity may contribute to this different phenotype. We used transcriptome profiling of 1503 innate immunity genes in primary CD4+ T cells and permissive
Ciuffi, A. +5 more
core +4 more sources
Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]
, 2020 The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia +4 more
core +2 more sources
Proceedings of the National Academy of Sciences, 2004 The capacity to mount an immune response that eliminates infection of a host by a microbial pathogen is critical for species survival and propagation. Mammals have developed complex immune systems that integrate innate responses, such as phagocytosis and the production of antimicrobial peptides after Toll-like receptor activation, along with adaptive ...
John A T, Young, Andrew, Dillin
openaire +2 more sources
Metabolites, 2020 Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach +2 more
doaj +1 more source
Reviewing the effects of food provisioning on wildlife immunity [PDF]
, 2018 While urban expansion increasingly encroaches on natural habitats, many wildlife species capitalize on anthropogenic food resources, which have the potential to both positively and negatively influence their responses to infection.
Babayan, Simon A. +2 more
core +1 more source
Western lifestyle linked to maladaptive trained immunity
eLifeTrained immunity (TI) refers to a state of innate immune cells that, after encountering an initial stimulus and undergoing epigenetic reprogramming and metabolic changes, allows them to respond more effectively to a subsequent challenge.
Aurelia Josephine Merbecks +5 more
doaj +1 more source
Nature Communications, 2022 Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft +9 more
doaj +1 more source
mBio, 2023 Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells.
Xuqiu Lei +3 more
doaj +1 more source
Subversion of host innate immunity by uropathogenic Escherichia coli [PDF]
, 2016 Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract infections (UTI) and represent a major etiologic agent of healthcare-associated UTI.
Cavalieri +5 more
core +3 more sources
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
Nature Communications, 2019 RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone +4 more
doaj +1 more source