Results 1 to 10 of about 109,193 (265)

The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation

Frontiers in Immunology, 2022
The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood.
Zhihao Xu, Shasha Deng, Yuluo Huang, Yunru Yang, Liangqi Sun, Hanyuan Liu, Dan Zhao, Weihong Zeng, Xueying Yin, Peiyi Zheng, Yingying Wang, Muziying Liu, Weidong Zhao, Tsan Sam Xiao, Ying Zhou, Tengchuan Jin, Tengchuan Jin, Tengchuan Jin   +17 more
doaj   +1 more source

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Do-Wan Shim, Kwang-Ho Lee, Kwang-Ho Lee
doaj   +1 more source

Interplay Between NLRP3 Inflammasome and Autophagy

Frontiers in Immunology, 2020
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators (DAMPs).
Monika Biasizzo, Monika Biasizzo, Nataša Kopitar-Jerala   +2 more
doaj   +1 more source

A new acid isolated from V. negundo L. inhibits NLRP3 inflammasome activation and protects against inflammatory diseases

Frontiers in Immunology, 2023
The NLRP3 inflammasome plays a critical role in the innate immune response, and its excessive activation will cause pyroptotic cell death and be associated with the onset of inflammatory diseases. However, NLRP3 inflammasome targeting therapies are still
Qianqian Di, Xibao Zhao, Jing Lin, Xunwei Li, Xiaoli Li, Haimei Tang, Ruihan Zhang, Weilie Xiao, Weilin Chen   +8 more
doaj   +1 more source

Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders

Frontiers in Immunology, 2022
The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential role in the innate immune system by identifying and eliminating a plethora of endogenous and exogenous threats to the host.
Bora Tastan, Bora Tastan, Burak I. Arioz, Burak I. Arioz, Sermin Genc, Sermin Genc   +5 more
doaj   +1 more source

Nanoreporter for Real‐Time Monitoring of Inflammasome Activity and Targeted Therapy

Advanced Science, 2023
Inflammasome activation is associated with a myriad of inflammatory diseases. However, existing methods provides a limited understanding of spatiotemporal kinetics of inflammasome activation, with restricted scope for early detection of associated ...
Dipika Nandi, James Forster III, Anujan Ramesh, Anh Nguyen, Hariharan Bharadwaj, Ashish Kulkarni   +5 more
doaj   +1 more source

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

Molecules, 2020
Chalcones are responsible for biological activity throughout fruits, vegetables, and medicinal plants in preventing and treating a variety of inflammation-related diseases.
Wohn-Jenn Leu, Jung-Chun Chu, Jui-Ling Hsu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Wei-Jan Huang, Jih-Hwa Guh   +7 more
doaj   +1 more source

Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies

Biochemistry and Biophysics Reports, 2023
Chronic kidney disease (CKD) is a global health concern and public health priority. The condition often involves inflammation due to the accumulation of toxins and the reduced clearance of inflammatory cytokines, leading to gradual loss of kidney ...
Gengzhen Huang, Yaodan Zhang, Yingying Zhang, Yuerong Ma   +3 more
doaj   +1 more source

Phosphorylation of NLRP6 at Serine 27 site is critical for NLRP6 inflammasome activation and neurological impairment in ischemic stroke

Cell Communication and Signaling
Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 6 (NLRP6) is a pattern recognition receptor that is highly expressed in microglia and forms a cytosolic inflammasome to aggravate neuroinflammation and neuronal injury during
Junyi Tan, Meng Wang, Keli Huang, Mao Xie, Yaling Zheng, Jing Luo, Jiutang Tang, Xuan Zhai, Qi He, Jing Zhao   +9 more
doaj   +1 more source

NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Clinical and Translational Medicine, 2020
Inflammation is an important process involved in several cardiovascular diseases (CVDs), and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital player in innate immunity and inflammation.
Yucheng Wang, Xiaoxiao Liu, Hui Shi, Yong Yu, Ying Yu, Minghui Li, Ruizhen Chen   +6 more
doaj   +1 more source