Results 1 to 10 of about 89,752 (156)
S-Nitrosoglutathione protects acute kidney injury in septic rats by inhibiting the activation of NLRP3 inflammasome [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): We aimed to study the effect of S-nitroso glutathione (SNG) on acute kidney injury (AKI) in septic rats by regulating nucleotide oligomerization domain-like receptor protein 3 (NLRP3).Materials and Methods: Sprague Dawley rats were used to ...
Heng Fan +3 more
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Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu +11 more
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Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy +2 more
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NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation [PDF]
International Journal of Molecular Sciences, 2021 In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response.
Mahbuba Akther +4 more
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Journal of Clinical Immunology, 2019 Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory ...
Laela M. Booshehri, Hal M. Hoffman
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Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells
Cells, 2020 Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and the brain. Experimental and clinical studies have suggested the presence of neuroinflammation in schizophrenia.
Vijayasree V. Giridharan +9 more
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Archives of Pharmaceutical Sciences Ain Shams University, 2023 Background: Breast cancer (BC) is considered the main cause of death in women worldwide. Overexpression of Sphingosine 1-phosphate (S1P) receptors in estrogen receptor (ER) negative BC patients is linked to poor prognosis.
Anas R. Soltan +3 more
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Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Journal of Inflammation Research, 2021 Nan Ji,1,2,* Zhongwen Qi,1,* Yueyao Wang,1 Xiaoya Yang,1 Zhipeng Yan,1 Meng Li,1 Qihui Ge,1 Junping Zhang1 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People’s Republic of China; 2National ...
Ji N +7 more
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Diabetes, Metabolic Syndrome and Obesity, 2021 Tianyu Meng,1,* Jie Wang,2,3,* Manyun Tang,2 Shangyu Liu,4 Ligang Ding,4 Yang Yan5 1Department of Geriatrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Department of
Meng T +5 more
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The EMBO Journal, 2023 Abstract The NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 inflammasome forms multiprotein complexes and its sequential assembly is important for its activation.
Yeon‐Ji Park +11 more
openaire +2 more sources