Results 1 to 10 of about 113,850 (298)

NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation [PDF]

International Journal of Molecular Sciences, 2021
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response.
Mahbuba Akther, Md Ezazul Haque, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee   +4 more
openaire   +3 more sources

MARCH5 ‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation

EMBO Journal, 2023
Abstract The NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 inflammasome forms multiprotein complexes and its sequential assembly is important for its activation.
Jong-Soo Lee, Niranjan Dodantenna, Hyeseong Cho   +2 more
exaly   +3 more sources

Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA

International Journal of Nanomedicine, 2023
Jing Huang,1,* Mengmeng Dai,1,* Mingxia He,1,* Weicheng Bu,1 Liwen Cao,1 Jing Jing,1 Run Cao,1 Hailong Zhang,1 Ke Men2 1Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital, Henan University, Kaifeng, Henan ...
Huang J, Dai M, He M, Bu W, Cao L, Jing J, Cao R, Zhang H, Men K   +8 more
doaj   +1 more source

The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation [PDF]

, 2021
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome pathways, can increase the rate of opportunistic infection.
openaire   +4 more sources

S-Nitrosoglutathione protects acute kidney injury in septic rats by inhibiting the activation of NLRP3 inflammasome [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): We aimed to study the effect of S-nitroso glutathione (SNG) on acute kidney injury (AKI) in septic rats by regulating nucleotide oligomerization domain-like receptor protein 3 (NLRP3).Materials and Methods: Sprague Dawley rats were used to ...
Heng Fan, sun Min, Le Jian-wei, Zhu Jian-hua   +3 more
doaj   +1 more source

Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu, Mengnan Zeng, Pengli Guo, Yuhan Zhang, Xiaofeng Yang, Jufang Jia, Qinqin Zhang, Beibei Zhang, Bing Cao, Ru Wang, Xiaoke Zheng, Weisheng Feng   +11 more
doaj   +1 more source

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress [PDF]

, 2023
NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and ...
Mélanie Bodnar-Wachtel, Annabelle Ballesta, Janet Hall, Hall, Janet, Guey, Baptiste, Sylvie Lantuejoul, François Ghiringhelli, Truntzer, Caroline, Couté, Yohann, Elise Ballot, Huber, Anne-Laure, Lantuejoul, Sylvie, Baptiste Guey, Lecuelle, Julie, Sabine Hacot, Ghiringhelli, François, Anne-Laure Huber, Bodnar-Wachtel, Mélanie, Agnès Tissier, Delphine Burlet, Caroline Truntzer, Bénédicte F Py, Gérossier, Laetitia, Goutagny, Nadège, Laetitia Gérossier, Birke Bartosch, Bartosch, Birke, Julie Lecuelle, Burlet, Delphine, Virginie Petrilli, Ballot, Elise, Yohann Couté, Hacot, Sabine, Gorry, Julie, Nadège Goutagny, Py, Bénédicte F, Ballesta, Annabelle, Tissier, Agnès, Py, Bénédicte, F, Petrilli, Virginie, Julie Gorry   +40 more
core   +1 more source

Inhibiting the NLRP3 Inflammasome [PDF]

Molecules, 2020
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy, David Brough, Sally Freeman   +2 more
openaire   +4 more sources

Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells

Cells, 2020
Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and the brain. Experimental and clinical studies have suggested the presence of neuroinflammation in schizophrenia.
Vijayasree V. Giridharan, Giselli Scaini, Gabriela D. Colpo, Tejaswini Doifode, Omar F. Pinjari, Antônio L. Teixeira, Fabricia Petronilho, Danielle Macêdo, João Quevedo, Tatiana Barichello   +9 more
doaj   +1 more source

CAPS and NLRP3 [PDF]

Journal of Clinical Immunology, 2019
Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory ...
Laela M. Booshehri, Hal M. Hoffman
openaire   +2 more sources