Results 1 to 10 of about 525,635 (287)

IKKα regulation of canonical NF-κB activation downstream of Nod1-mediated peptidoglycan recognition : "and" Endocytosis-independent function of clathrin heavy chain in the control of basal NF-κB activation [PDF]

, 2010
NF-κB is a transcription factor involved in the regulation of inflammation and innate immunity. The IκB kinase (IKK) complex contains two catalytic subunits, IKKα and IKKβ, and plays an essential role in the activation of NF-κB through the phosphorylation and degradation of the NF-κB inhibitor IκBα, thereby allowing translocation of NF-κB into the ...
Kim, Man Lyang
openaire   +4 more sources

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma [PDF]

Frontiers in Oncology, 2023
IntroductionImproving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL. Transcriptionally active NF-κB is a dimer containing
Eleanor Jayawant, Arran Pack, Heather Clark, Emma Kennedy, Ankur Ghodke, John Jones, Chris Pepper, Andrea Pepper, Simon Mitchell   +8 more
doaj   +4 more sources

Maternal Wnt/β-Catenin Signaling Coactivates Transcription through NF-κB Binding Sites during Xenopus Axis Formation [PDF]

PLoS ONE, 2012
Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also on a MyD88-dependent Toll-like receptor/IL1-receptor (TLR/IL1-R) signaling pathway.
Armstrong, Neil J., Fagotto, François, Prothmann, Christian, Rupp, Ralph A. W.   +3 more
openaire   +7 more sources

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway [PDF]

PLoS ONE, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Montaseri A., Busch F., Mobasheri A., Buhrmann C., Aldinger C., Rad J. S., Shakibaei M.   +6 more
openaire   +9 more sources

Extracellular flux analysis to investigate the impact of NF-κB on mitochondrial respiration in colorectal carcinoma (CRC). [PDF]

, 2021
The reprogramming of cell metabolism is a hallmark of cancer. NF-κB transcription factors coordinate the host defense responses to stress, injury, and infection. They also play a central role in oncogenesis, at least in part by regulating cell metabolism
Zazzeroni, F, Guido Franzoso, Francesca Zazzeroni, Verzella, D, Capece, D, Capece, Daria, Bennett, Jason, Davide Vecchiotti, D'Andrea, Daniel, D'Andrea, D, Begalli, F, Vecchiotti, D, Daniel D’Andrea, Verzella, Daniela, Franzoso, Guido, Begalli, Federica, Daniela Verzella, Federica Begalli, Jason Bennett, Vecchiotti, Davide, Bennett, J, Zazzeroni, Francesca, Daria Capece, Franzoso, G   +23 more
core   +2 more sources

NF‐κB signaling in inflammation and cancer

MedComm, 2021
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF‐κB for 35 years, which lead to significant progress ...
Tao Zhang, Chao Ma, Zhiqiang Zhang, Huiyuan Zhang, Hongbo Hu   +4 more
doaj   +1 more source

Hepatic NF‐κB‐Inducing Kinase and Inhibitor of NF‐κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury

Hepatology Communications, 2021
Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS has broad
Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue‐Gong Fan, Liangyou Rui   +7 more
doaj   +1 more source

Expression of HMGB1 and NF-κB in Fetal Membranes of Premature Rupture of Membranes

Althea Medical Journal, 2023
Background: Inflammation, either sterile or infection-related, may lead to premature rupture of membranes (PROM). The non-histone nuclear proteins, high mobility group box-1 (HMGB1), and nuclear factor kappa-B (NF-κB) transcription factors have been extensively investigated in many disorders involving inflammatory reactions.
Ketut Edy Sudiarta, Joan Khan, Monicha Zalzabilla Aldinasyah, Efyluk Garianto, Retno Budiarti   +4 more
openaire   +2 more sources

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Immunity, Inflammation and Disease, 2023
Objective In this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.
Maryam Ghasemi‐Dehnoo, Zahra Lorigooini, Hossein Amini‐Khoei, Milad Sabzevary‐Ghahfarokhi, Mahmoud Rafieian‐Kopaei   +4 more
doaj   +1 more source

NF-kB decoy oligodeoxynucleotide preserves disc height in a rabbit anular-puncture model and reduces pain induction in a rat xenograft-radiculopathy model [PDF]

European Cells & Materials, 2021
While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is
K Kato, K Akeda, S Miyazaki, J Yamada, C Muehleman, K Miyamoto, YA Asanuma, K Asanuma, T Fujiwara, ME Lenz, T Nakazawa, H An, K Masuda   +12 more
doaj   +1 more source