An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia [PDF]
The Journal of Immunology, 2011 Abstract Hypoxia is a feature of the microenvironment in a number of chronic inflammatory conditions due to increased metabolic activity and disrupted perfusion at the inflamed site. Hypoxia contributes to inflammation through the regulation of gene expression via key oxygen-sensitive transcriptional regulators including the hypoxia ...
S.F. Fitzpatrick +13 more
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Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +6 more
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NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]
, 2011 NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela +20 more
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Understanding NF‐κB signaling via mathematical modeling
Molecular Systems Biology, 2008 Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be regulated to produce different yet specific responses to different inflammatory insults. Mathematical
Raymond Cheong +2 more
doaj +1 more source
Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
Biomolecules, 2020 The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including ...
Aishat Motolani +3 more
doaj +1 more source
Nuclear factor-kappa B inhibition can enhance apoptosis of differentiated thyroid cancer cells induced by 131I. [PDF]
PLoS ONE, 2012 OBJECTIVE: To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 ((131)I) therapy and whether NF-κB inhibition could enhance (131)I-induced apoptosis in differentiated thyroid cancer (DTC) cells in a synergistic manner.
Zhaowei Meng +5 more
doaj +1 more source
NF-κB mediated the effect of GDNF on CXCL1 and proliferation in rat C6 glioma cells. [PDF]
, 2023 (A) Western blot showed that NF-κB mediated the effect of exogenous GDNF on CXCL1. (B) The statistical results of (A). (C) NF-κB mediated GDNF enhanced the activity of CXCL1 gene promoter region by double luciferase reporter gene activity.
Dian Shuai Gao (16851471) +5 more
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NF-κB response with flow and degradation. [PDF]
, 2016 (A) Representative images from confocal microscopy of NF-κB (green) and nuclear counterstain (red) following exposure to different flow times. Images were acquired at 10x magnification (scale bar = 50μm).
Scott Cooper (3373172) +3 more
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Kaohsiung Journal of Medical Sciences, 2012 Modulation of nuclear factor-kappa B (NF-κB) expression has important clinical implications including anti-inflammation. Recently, we have shown that direct regulation of NF-κB/p65 subunit may account for tacrolimus ointment’s remarkable clinical ...
Ching-Shuang Wu +5 more
doaj +1 more source
Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression [PDF]
Nature Communications, 2018 AbstractKnowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation.
Feist, M. +18 more
openaire +5 more sources