Results 21 to 30 of about 495,858 (236)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma

, 2023
Introduction: Improving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL.
John Jones (9533897), A Ghodke (16507989), Emma Kennedy (10950165), H Clark (11605071), Simon Mitchell (6828470), A Pack (16507986), Andrea Pepper (4467784), Eleanor Jayawant (10656704), Christopher Pepper (4467913)   +8 more
core   +1 more source

Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-κB pathway

Cellular and Molecular Biology, 2019
Effect of ginkgetin on proliferation of human cervical cancer (HeLa) cells and the underlying mechanism   were investigated. Human cervical cancer (HeLa) cells were cultured at 37 °C in 10 % fetal bovine serum (FBS) supplemented RPMI 1640 medium in a humidified incubator containing 5 % CO2.
Jianxia, Cheng, Yun, Li, Jianping, Kong
openaire   +3 more sources

NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

, 2021
International audienceConventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8 + T cells, promoting the expansion of tumor-specific cytotoxic T cells ...
Manh, Thien, Ghislat, Ghita, Baudoin, Elodie, Auphan-Anezin, Nathalie, Crozat, Karine, Vu Manh, Thien P., Ballester, Pedro J., Attaf, Noudjoud, Verthuy, Christophe, Malissen, Bernard, Cheema, Ammar S., Dong, Chuang, Lawrence, Toby, Cheema, Ammar, Milpied, Pierre, Ballester, Pedro, Dalod, Marc   +16 more
core   +1 more source

Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells [PDF]

FEMS Immunology & Medical Microbiology, 2007
Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity. Glucocorticoids, on the other hand, exert immunosuppressive and anti-inflammatory actions. We have previously reported that interleukin (IL)-1beta induces HBD-2 mRNA expression through the activation of nuclear factor-kappaB (NF-kappaB ...
Byeong-Churl Jang, Ki-Jo Lim, Min-Ho Suh, Jong-Gu Park, Seong-Il Suh   +4 more
openaire   +3 more sources

MOESM1 of Amentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF-κB pathways

, 2019
Additional file 1. Assessment of inflammation due to cold stress.
Cai, Jiayi, Zhao, Chunyang, Du, Yajie, Huang, Yuan, Zhao, Qingchun   +4 more
openaire   +1 more source

Kombinasi Artemisinin dan Ekstrak Moringa oleifera Menurunkan Ekspresi NF-κB namun Tidak Menurunkan Ekspresi iNOS pada Otak Mencit Diinfeksi Malaria

Jurnal Kedokteran Brawijaya, 2015
Malaria otak merupakan manifestasi tersering dari infeksi malaria berat yang ditandai dengan respon inflamasi berlebih di otak. Untuk mencegah terjadinya resistensi, penggunaan obat antimalaria standar (artemisinin) harus dikombinasikan dengan obat antimalaria lain.
Herpan Syafii Harahap, Mochammad Dalhar, Tinny Endang Endang H, Eviana Norahmawati, Loeki Enggar Fitri   +4 more
openaire   +2 more sources

Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway

Cellular and Molecular Biology, 2019
To investigate the effect of gentiopicrin on the expressions of inflammatory factors in human fibroblast-like synoviocytes (HFLS) and the underlying mechanism. Human fibroblast-like synoviocytes (HFLS) were cultured in vitro at 37 °C in Dulbecco's modified Eagle's medium (DMEM) supplemented with 5 % fetal bovine serum (FBS) in a humidified incubator ...
Nian, Zhang, Yi, Jiang, Fangxiang, Mu, Hong, Wu, Qingxia, You   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB [PDF]

Frontiers in Immunology, 2014
The mammalian tumor necrosis factor (TNF) cytokine is a central mediator of inflammatory events. Recent studies revealed a number of complex and sophisticated interactions between the TNF pathway and the enzymatic activities encoded by ubiquitin ligases and deubiquitylation enzymes.
Brittany eFraser, Brittany eFraser, Robert A Maranchuk, Robert A Maranchuk, Edan eFoley, Edan eFoley   +5 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source