Results 21 to 30 of about 577,005 (273)
NF-kappa B activation correlates with disease phenotype in Crohn's disease. [PDF]
PLoS ONE, 2017 Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB
Yoo Min Han +8 more
doaj +1 more source
Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]
, 2007 Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Yue, H. +4 more
core +3 more sources
NF-κB signaling regulates myelination in the CNS [PDF]
Frontiers in Molecular Neuroscience, 2014 Besides myelination of neuronal axons by oligodendrocytes to facilitate propagation of action potentials, oligodendrocytes also support axon survival and function. A key transcription factor involved in these processes is nuclear factor-κB (NF-κB), a hetero or homodimer of the Rel family of proteins, including p65, c-Rel, RelB, p50, and p52.
Thomas eBlank +2 more
openaire +3 more sources
TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes
Alad, 2022 Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes. Material and methods: Platelet aggregation was determined by light transmission and protein expression by flow cytometry in 31 patients and 29 controls from Yucatan ...
LucÃa G. González-Espinosa +7 more
openaire +2 more sources
Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Cells, 2016 The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development.
Véronique Baud, Davi Collares
doaj +1 more source
NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
Biomedicines, 2021 Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers,
Thomas D. Gilmore
doaj +1 more source
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation [PDF]
Frontiers in Genetics, 2014 Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age.
Cheng, Henry S. +4 more
openaire +3 more sources
Understanding NF‐κB signaling via mathematical modeling
Molecular Systems Biology, 2008 Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be regulated to produce different yet specific responses to different inflammatory insults. Mathematical
Raymond Cheong +2 more
doaj +1 more source
Nuclear factor-kappa B inhibition can enhance apoptosis of differentiated thyroid cancer cells induced by 131I. [PDF]
PLoS ONE, 2012 OBJECTIVE: To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 ((131)I) therapy and whether NF-κB inhibition could enhance (131)I-induced apoptosis in differentiated thyroid cancer (DTC) cells in a synergistic manner.
Zhaowei Meng +5 more
doaj +1 more source
An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia [PDF]
The Journal of Immunology, 2011 Abstract Hypoxia is a feature of the microenvironment in a number of chronic inflammatory conditions due to increased metabolic activity and disrupted perfusion at the inflamed site. Hypoxia contributes to inflammation through the regulation of gene expression via key oxygen-sensitive transcriptional regulators including the hypoxia ...
S.F. Fitzpatrick +13 more
openaire +3 more sources