Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]
, 2013 As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines +4 more
core +3 more sources
Understanding NF‐κB signaling via mathematical modeling
Molecular Systems Biology, 2008 Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be regulated to produce different yet specific responses to different inflammatory insults. Mathematical
Raymond Cheong +2 more
doaj +1 more source
Regulation of NF-κB activity through lysine monomethylation of p65 [PDF]
, 2009 NF-κB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-κB is regulated by different posttranslational modifications.
Baltimore, David, Ea, Chee-Kwee
core +3 more sources
Kaohsiung Journal of Medical Sciences, 2012 Modulation of nuclear factor-kappa B (NF-κB) expression has important clinical implications including anti-inflammation. Recently, we have shown that direct regulation of NF-κB/p65 subunit may account for tacrolimus ointment’s remarkable clinical ...
Ching-Shuang Wu +5 more
doaj +1 more source
Listeria monocytogenesinfection of Caco-2 human epithelial cells induces activation of transcription factor NF-κB/Rel-like DNA binding activities [PDF]
FEMS Microbiology Letters, 1999 The effect of Listeria monocytogenes infection on the cellular level of transcription factor NF-kappa B in the human epithelia-like cell line Caco-2 was investigated. Infection with L. monocytogenes or treatment with lipoteichoic acid induced the formation of three NF-kappa B-like DNA-protein complexes C1, C2, and C3, which were identified as ...
N, Hauf, W, Goebel, F, Fiedler, M, Kuhn
openaire +2 more sources
Translational Psychiatry, 2021 Bipolar disorder and schizophrenia have multiple clinical and genetic features in common, including shared risk associated with overlapping susceptibility loci in immune-related genes. Higher activity of the nuclear factor-κB (NF-κB) transcription factor
Kaitlyn M. Roman +3 more
doaj +1 more source
Restoring Conjunctival Tolerance by Topical Nuclear Factor–κB Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice [PDF]
, 2014 Purpose.: To evaluate the role of nuclear factor–κB (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis.
Gabelloni, María Laura +6 more
core +1 more source
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation [PDF]
Frontiers in Genetics, 2014 Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age.
Cheng, Henry S. +4 more
openaire +3 more sources
Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]
, 2015 The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert +12 more
core +4 more sources
The Regulation of NF-κB Subunits by Phosphorylation
Cells, 2016 The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle ...
Frank Christian +2 more
doaj +1 more source