Results 31 to 40 of about 577,005 (273)

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer

Biomolecules, 2020
The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including ...
Aishat Motolani, Matthew Martin, Mengyao Sun, Tao Lu   +3 more
doaj   +1 more source

The Neutrophil Gelatinase-associated lipocalin (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells [PDF]

, 2008
NF-κB is constitutively activated in primary human thyroid tumors, particularly in those of anaplastic type. The inhibition of NF-κB activity in the human anaplastic thyroid carcinoma cell line, FRO, leads to an increased susceptibility to ...
Iannetti, Alessio
core   +1 more source

Differential regulation of nuclear factor-kappa B subunits on epidermal keratinocytes by ultraviolet B and tacrolimus

Kaohsiung Journal of Medical Sciences, 2012
Modulation of nuclear factor-kappa B (NF-κB) expression has important clinical implications including anti-inflammation. Recently, we have shown that direct regulation of NF-κB/p65 subunit may account for tacrolimus ointment’s remarkable clinical ...
Ching-Shuang Wu, Cheng-Che E. Lan, Hsuan-Yu Kuo, Chee-Yin Chai, Wan-Tzu Chen, Gwo-Shing Chen   +5 more
doaj   +1 more source

Involvement of the nuclear factor-κB transcriptional complex in prefrontal cortex immune activation in bipolar disorder

Translational Psychiatry, 2021
Bipolar disorder and schizophrenia have multiple clinical and genetic features in common, including shared risk associated with overlapping susceptibility loci in immune-related genes. Higher activity of the nuclear factor-κB (NF-κB) transcription factor
Kaitlyn M. Roman, Aaron K. Jenkins, David A. Lewis, David W. Volk   +3 more
doaj   +1 more source

Ekspresi dan Aktivasi Sub Unit p65 NF-κB pada Sel Mononuklear Penderita Sindrom Nefrotik Resisten Steroid Anak

Jurnal Kedokteran Brawijaya, 2013
Resitance  to  steroid  therapy  is  a  poor  prognosis  sign  for  nephrotic  syndrome,  but  this  mechanism is  still unclear. NF-κB has been reported to affect the glucocorticoid at the T cell through the transrepression in  the glucocorticoid  receptor .  Until  know,  this  study  was  still  limited.  The  aim  of  
Brigitta Ida RV Corebima, Krisni Subandiyah, Loeki Enggar Fitri   +2 more
openaire   +2 more sources

A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. [PDF]

PLoS ONE, 2013
Previous studies have implicated NF-κB signaling in both cutaneous development and oncogenesis. However, these studies have been limited in part by the lethality that results from extreme over- or under-expression of NF-κB in available mouse models. Even
Brian Poligone, Matthew S Hayden, Luojing Chen, Alice P Pentland, Eijiro Jimi, Sankar Ghosh   +5 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression [PDF]

Nature Communications, 2018
AbstractKnowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation.
Feist, M., Schwarzfischer, Philipp, Heinrich, Paul, Sun, Xueni, Kemper, J., von Bonin, F., Perez-Rubio, Paula, Taruttis, Franziska, Rehberg, Thorsten, Dettmer, Katja, Gronwald, Wolfram, Reinders, Jörg, Engelmann, Julia C., Dudek, J., Klapper, W., Trumper, L., Spang, Rainer, Oefner, Peter J., Kube, D.   +18 more
openaire   +4 more sources

The Regulation of NF-κB Subunits by Phosphorylation

Cells, 2016
The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle ...
Frank Christian, Emma L. Smith, Ruaidhrí J. Carmody   +2 more
doaj   +1 more source

Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]

, 2010
INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna, Moore, CE, Davies, RJ, J Scott, Adrian VS Hill, Shelley Segal, Berkley, James, Hill, Adrian, Chiea C Khor, Andrew Walley, Catrin E Moore, Hill, AVS, Peshu, N, Davies, Robert JO, Scott, John, Williams, TN, Chapman, Stephen J, James A Berkley, Segal, S, Rautanen, A, Hill, AV, Scott, J Anthony, Fredrik O Vannberg, Walley, A, Khor, Chiea C, Vannberg, Fredrik O, Davies, RJO, Khor, CC, Derrick W Crook, Crook, DW, Moore, Catrin E, Berkley, James A, Segal, Shelley, Berkley, JA, Norbert Peshu, Hill, Adrian VS, Crook, Derrick W, Thomas N Williams, Day, Nicholas P, Day, NP, Vannberg, FO, Peshu, Norbert, Chapman, SJ, Scott, JA, Stephen J Chapman, Nicholas P Day, Anna Rautanen, Williams, Thomas N, Day, Nicholas, Walley, Andrew, Williams, Thomas, Robert JO Davies   +51 more
core   +1 more source