Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases [PDF]
Cells, 2020 Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS).
Stefan Dubel +2 more
exaly +4 more sources
NF-kappaB in Lung Tumorigenesis [PDF]
Cancers, 2011 The development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis.
Kam-Meng Tchou-Wong +2 more
exaly +3 more sources
Cyclovirobuxine D suppresses cancer stemness in osteosarcoma with implication of the noncanonical NF-kappaB pathway [PDF]
Frontiers in PharmacologyBackgroundCyclovirobuxine D (CVB-D), an alkaloid from Buxus microphylla, exhibits anticancer effects in various tumors, but its role in osteosarcoma remains unexplored. This study investigates its efficacy and mechanism in osteosarcoma.MethodsWe screened
Jinku Guo +14 more
doaj +2 more sources
Chitin Extracted from the Shell of Blue Swimming Crabs (Portunus pelagicus Linn.) Inhibits NF-kappaB p65 in Ethanol-Induced Gastric Ulcerative Wistar Rats [PDF]
Marine Drugs, 2023 Peptic ulcer disease is generated by the activation of NF-kappaB activity. A recent clinical study reported a significant increase in NF-kappaB2 gene expression in 79 samples of peptic ulcer patients compared to the control group.
Renny Amelia +3 more
doaj +2 more sources
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro [PDF]
Frontiers in Physiology, 2019 Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the development of non-OA inflammatory disease. However, the precise involvement
He Zhang +7 more
doaj +2 more sources
Biomedicines, 2022 Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and ...
Stéphanie Nuan-Aliman +3 more
doaj +1 more source
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. [PDF]
PLoS ONE, 2009 NF-kappaB is a prototypic stress-responsive transcription factor that acts within a complex regulatory network. The signaling dynamics of endogenous NF-kappaB in single cells remain poorly understood.
Myong-Hee Sung +7 more
doaj +1 more source
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. [PDF]
PLoS ONE, 2007 Alcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors of Nuclear Factor-kappaB (
Anna Okvist +15 more
doaj +1 more source
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. [PDF]
PLoS ONE, 2009 Limited information is available on the molecular mechanisms associated with Campylobacter jejuni (C. jejuni) induced food-borne diarrheal illnesses. In this study, we investigated the function of TLR/NF-kappaB signaling in C. jejuni induced pathogenesis
Elisabeth Lippert +6 more
doaj +1 more source
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. [PDF]
PLoS ONE, 2009 The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes.
Zorica Janjetovic +6 more
doaj +1 more source