Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases [PDF]
Cells, 2020 Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS).
Stefan Dübel +2 more
exaly +4 more sources
Cyclovirobuxine D suppresses cancer stemness in osteosarcoma with implication of the noncanonical NF-kappaB pathway [PDF]
Frontiers in PharmacologyBackgroundCyclovirobuxine D (CVB-D), an alkaloid from Buxus microphylla, exhibits anticancer effects in various tumors, but its role in osteosarcoma remains unexplored. This study investigates its efficacy and mechanism in osteosarcoma.MethodsWe screened
Jinku Guo +14 more
doaj +2 more sources
Chitin Extracted from the Shell of Blue Swimming Crabs (Portunus pelagicus Linn.) Inhibits NF-kappaB p65 in Ethanol-Induced Gastric Ulcerative Wistar Rats [PDF]
Marine Drugs, 2023 Peptic ulcer disease is generated by the activation of NF-kappaB activity. A recent clinical study reported a significant increase in NF-kappaB2 gene expression in 79 samples of peptic ulcer patients compared to the control group.
Renny Amelia +3 more
doaj +2 more sources
Biomedicines, 2022 Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and ...
Stéphanie Nuan-Aliman +3 more
doaj +1 more source
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. [PDF]
PLoS ONE, 2009 NF-kappaB is a prototypic stress-responsive transcription factor that acts within a complex regulatory network. The signaling dynamics of endogenous NF-kappaB in single cells remain poorly understood.
Myong-Hee Sung +7 more
doaj +1 more source
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. [PDF]
PLoS ONE, 2007 Alcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors of Nuclear Factor-kappaB (
Anna Okvist +15 more
doaj +1 more source
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. [PDF]
PLoS ONE, 2009 Limited information is available on the molecular mechanisms associated with Campylobacter jejuni (C. jejuni) induced food-borne diarrheal illnesses. In this study, we investigated the function of TLR/NF-kappaB signaling in C. jejuni induced pathogenesis
Elisabeth Lippert +6 more
doaj +1 more source
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. [PDF]
PLoS ONE, 2009 The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes.
Zorica Janjetovic +6 more
doaj +1 more source
The type III secretion effector NleE inhibits NF-kappaB activation. [PDF]
PLoS Pathogens, 2010 The complex host-pathogen interplay involves the recognition of the pathogen by the host's innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-
Chen Nadler +10 more
doaj +1 more source
Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons. [PDF]
PLoS ONE, 2007 Long-term changes in synaptic plasticity require gene transcription, indicating that signals generated at the synapse must be transported to the nucleus. Synaptic activation of hippocampal neurons is known to trigger retrograde transport of transcription
Ilja Mikenberg +4 more
doaj +1 more source