NF-kappaB in Lung Tumorigenesis [PDF]
Cancers, 2011 The development of lung cancer in humans can be divided into three steps: initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis.
Zhenjian Cai, Kam-Meng Tchou-Wong
exaly +3 more sources
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
Cells, 2020 Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS).
Stefan Dubel +2 more
exaly +3 more sources
Noncanonical NF-kappaB Signaling Is Limited by Classical NF-kappaB Activity.
, 2014 Precise regulation of nuclear factor kappaB (NF-kappaB) signaling is crucial for normal immune responses, and defective NF-kappaB activity underlies a range of immunodeficiencies. NF-kappaB is activated through two signaling cascades: the classical and noncanonical pathways.
Gray, Carolyn M. +6 more
openaire +3 more sources
Biomedicines, 2022 Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and ...
Stéphanie Nuan-Aliman +3 more
doaj +1 more source
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. [PDF]
PLoS ONE, 2009 NF-kappaB is a prototypic stress-responsive transcription factor that acts within a complex regulatory network. The signaling dynamics of endogenous NF-kappaB in single cells remain poorly understood.
Myong-Hee Sung +7 more
doaj +1 more source
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. [PDF]
PLoS ONE, 2007 Alcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors of Nuclear Factor-kappaB (
Anna Okvist +15 more
doaj +1 more source
Gnotobiotic IL-10; NF-kappaB mice develop rapid and severe colitis following Campylobacter jejuni infection. [PDF]
PLoS ONE, 2009 Limited information is available on the molecular mechanisms associated with Campylobacter jejuni (C. jejuni) induced food-borne diarrheal illnesses. In this study, we investigated the function of TLR/NF-kappaB signaling in C. jejuni induced pathogenesis
Elisabeth Lippert +6 more
doaj +1 more source
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. [PDF]
PLoS ONE, 2009 The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes.
Zorica Janjetovic +6 more
doaj +1 more source
The type III secretion effector NleE inhibits NF-kappaB activation. [PDF]
PLoS Pathogens, 2010 The complex host-pathogen interplay involves the recognition of the pathogen by the host's innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-
Chen Nadler +10 more
doaj +1 more source
NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS.
, 2013 The proper growth and elaboration of neural processes is essential for the establishment of a functional nervous system during development and is an integral feature of neural plasticity throughout life.
Valerie A. Hale (17254840) +3 more
core +5 more sources