Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication. [PDF]
PLoS ONE, 2008 Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1.
Gary D Bren +6 more
doaj +1 more source
Expanding the substantial interactome of NEMO using protein microarrays. [PDF]
PLoS ONE, 2010 Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals ...
Beau J Fenner +2 more
doaj +1 more source
The role of NF-kappaB in endometriosis
Frontiers in Bioscience, 2012 The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the importance of NF-kappaB in the pathophysiology of endometriosis. Constitutive activation of NF-kappaB has been shown
Apostolos, Kaponis +7 more
openaire +2 more sources
RelB-dependent stromal cells promote T-cell leukemogenesis. [PDF]
PLoS ONE, 2008 BACKGROUND: The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to ...
Nuno R dos Santos +7 more
doaj +1 more source
Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. [PDF]
PLoS ONE, 2014 Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival.
Tamar Canello +5 more
doaj +1 more source
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. [PDF]
PLoS ONE, 2009 The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis.Mice were fed a diet containing 0.5 and 2% TLE or
Young-Eun Joo +6 more
doaj +1 more source
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. [PDF]
PLoS ONE, 2010 Activation of the transcription factor NF-kappaB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkappaB proteins.
Mazhar Adli +3 more
doaj +1 more source
PLoS Pathogens, 2009 Nuclear factor (NF)-kappaB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kappaB occurs predominantly in the cytoplasm, where Tax1 binds NF-kappaB Essential Modulator (NEMO ...
Chloé Journo +11 more
doaj +1 more source
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. [PDF]
PLoS ONE, 2010 Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport.
Mairi J Hunter +5 more
doaj +1 more source
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. [PDF]
PLoS ONE, 2007 The flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown.To address the therapeutic impact of luteolin, NF-kappaB(EGFP) transgenic mice were fed a chow
Thomas Karrasch +3 more
doaj +1 more source