Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons. [PDF]
PLoS ONE, 2007 Long-term changes in synaptic plasticity require gene transcription, indicating that signals generated at the synapse must be transported to the nucleus. Synaptic activation of hippocampal neurons is known to trigger retrograde transport of transcription
Ilja Mikenberg +4 more
doaj +1 more source
Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin. [PDF]
PLoS ONE, 2009 The ability of the transcription factor NF-kappaB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-kappaB
Brian K Bednarski +2 more
doaj +1 more source
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. [PDF]
PLoS ONE, 2008 Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells.
Tzvia Abramson +2 more
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Two modes of transcriptional activation at native promoters by NF-kappaB p65. [PDF]
PLoS Biology, 2009 The NF-kappaB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation, and inflammation.
Dominic van Essen +3 more
doaj +1 more source
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. [PDF]
PLoS Pathogens, 2009 NF-kappaB and inflammasomes both play central roles in orchestrating anti-pathogen responses by rapidly inducing a variety of early-response cytokines and chemokines following infection.
Masmudur M Rahman +4 more
doaj +1 more source
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. [PDF]
PLoS ONE, 2010 Classical NF-kappaB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFalpha on skeletal muscle differentiation are mediated in part through sustained NF-kappaB ...
Swarnali Acharyya +9 more
doaj +1 more source
Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]
, 2010 Apicomplexan parasites within the genus <i>Theileria</i> have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte.
Weir, W. +8 more
core +1 more source
PLoS ONE, 2009 Optineurin is a ubiquitously expressed multifunctional cytoplasmic protein encoded by OPTN gene. The expression of optineurin is induced by various cytokines.
Cherukuri Sudhakar +3 more
doaj +1 more source
HIV gp120 induces, NF-kappaB dependent, HIV replication that requires procaspase 8. [PDF]
PLoS ONE, 2009 HIV envelope glycoprotein gp120 causes cellular activation resulting in anergy, apoptosis, proinflammatory cytokine production, and through an unknown mechanism, enhanced HIV replication.We describe that the signals which promote apoptosis are also ...
Gary D Bren +4 more
doaj +1 more source
"Re-educating" tumor-associated macrophages by targeting NF-kappaB [PDF]
, 2008 The nuclear factor kappaB (NF-kappaB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-kappaB in cancer in maintaining the immunosuppressive phenotype of tumor-associated ...
Balkwill, F.R. +23 more
core +1 more source