Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. [PDF]
PLoS ONE, 2009 The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis.Mice were fed a diet containing 0.5 and 2% TLE or
Young-Eun Joo +6 more
doaj +1 more source
RelB-dependent stromal cells promote T-cell leukemogenesis. [PDF]
PLoS ONE, 2008 BACKGROUND: The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to ...
Nuno R dos Santos +7 more
doaj +1 more source
Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. [PDF]
PLoS ONE, 2014 Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival.
Tamar Canello +5 more
doaj +1 more source
PLoS Pathogens, 2009 Nuclear factor (NF)-kappaB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kappaB occurs predominantly in the cytoplasm, where Tax1 binds NF-kappaB Essential Modulator (NEMO ...
Chloé Journo +11 more
doaj +1 more source
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. [PDF]
PLoS ONE, 2010 Activation of the transcription factor NF-kappaB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkappaB proteins.
Mazhar Adli +3 more
doaj +1 more source
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. [PDF]
PLoS ONE, 2010 Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport.
Mairi J Hunter +5 more
doaj +1 more source
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. [PDF]
PLoS ONE, 2007 The flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown.To address the therapeutic impact of luteolin, NF-kappaB(EGFP) transgenic mice were fed a chow
Thomas Karrasch +3 more
doaj +1 more source
Memory extinction entails the inhibition of the transcription factor NF-kappaB. [PDF]
PLoS ONE, 2008 In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation ...
Emiliano Merlo, Arturo Romano
doaj +1 more source
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. [PDF]
PLoS Pathogens, 2006 Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells.
Christian Grant +8 more
doaj +2 more sources
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. [PDF]
PLoS ONE, 2010 Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown.
Jung Nyeo Chun +14 more
doaj +1 more source