Results 31 to 40 of about 23,717 (182)

Memory extinction entails the inhibition of the transcription factor NF-kappaB. [PDF]

PLoS ONE, 2008
In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation ...
Emiliano Merlo, Arturo Romano
doaj   +1 more source

Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. [PDF]

PLoS Pathogens, 2006
Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells.
Christian Grant, Unsong Oh, Kazunori Fugo, Norihiro Takenouchi, Caitlin Griffith, Karen Yao, Timothy E Newhook, Lee Ratner, Steven Jacobson   +8 more
doaj   +2 more sources

Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. [PDF]

PLoS ONE, 2010
Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown.
Jung Nyeo Chun, Boae Choi, Kyung Wha Lee, Doo Jae Lee, Dong Hoon Kang, Joo Young Lee, In Sung Song, Hye In Kim, Sang-Hee Lee, Hyeon Soo Kim, Na Kyung Lee, Soo Young Lee, Kong-Joo Lee, Jaesang Kim, Sang Won Kang   +14 more
doaj   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

NF kappaB expression increases and CFTR and MUC1 expression decreases in the endometrium of infertile patients with hydrosalpinx: a comparative study

Reproductive Biology and Endocrinology, 2012
Background Hydrosalpinx are associated with infertility, due to reduced rates of implantation and increased abortion rates. The aims of this study were to investigate the expression of cystic fibrosis transmembrane conductance regulator (CFTR), nuclear ...
Song Yong, Wang Qiushi, Huang Wei, Xiao Li, Shen Licong, Xu Wenming   +5 more
doaj   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, EarlyView.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome

Frontiers in Immunology, 2014
T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10 and MALT1, which is required for TCR ...
Lisa M Minter, Hyun Mu Shin, Mulualem E Tilahun, Ok Hyun Cho, Karthik eChandiran, Christina Arieta Kuksin, Shilpa eKeerthivasan, Abdul H Fauq, Abdul H Fauq, Todd E Golde, Lucio eMiele, Margot eThome, Barbara A Osborne, Barbara A Osborne   +13 more
doaj   +1 more source

Clinical and molecular features of primary gliosarcoma with digital spatial whole‐transcriptome analysis of glial and mesenchymal components

Brain Pathology, Volume 36, Issue 5, September 2026.
We report the clinical and genetic features of an institutional cohort of primary adult gliosarcomas compared to glioblastoma. We performed spatial whole‐transcriptome analysis on glial and sarcomatous regions of four cases to compare gene expression profiles and validated differential protein expression for two markers in tissue sections.
Matthew D. Wood, Gabriel Zangirolani, Jinho Lee, Melanie H. Hakar, Tanaya Neff, Kevin Y. Zhang, Christopher L. Corless   +6 more
wiley   +1 more source

Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. [PDF]

PLoS ONE, 2009
BACKGROUND: Coenzyme Q (CoQ) is a lipophilic antioxidant that is synthesized by a mitochondrial complex integrated by at least ten nuclear encoded COQ gene products.
Gloria Brea-Calvo, Emilio Siendones, José A Sánchez-Alcázar, Rafael de Cabo, Plácido Navas   +4 more
doaj   +1 more source