Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities. [PDF]
PLoS ONE, 2009 NF-kappaB is an evolutionarily conserved transcription factor that controls the expression of genes involved in many key organismal processes, including innate immunity, development, and stress responses. NF-kappaB proteins contain a highly conserved DNA-
James C Sullivan +6 more
doaj +1 more source
The role of NF-kappaB in endometriosis
Frontiers in Bioscience, 2012 The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the importance of NF-kappaB in the pathophysiology of endometriosis. Constitutive activation of NF-kappaB has been shown
Apostolos, Kaponis +7 more
openaire +2 more sources
HIF-1α, a novel piece in the NF-κB puzzle [PDF]
, 2015 Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core +1 more source
Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication. [PDF]
PLoS ONE, 2008 Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1.
Gary D Bren +6 more
doaj +1 more source
Aberrant NF-kappaB expression in autism spectrum condition : a mechanism for neuroinflammation [PDF]
, 2011 Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the ...
Young, Adam +18 more
core +2 more sources
Expanding the substantial interactome of NEMO using protein microarrays. [PDF]
PLoS ONE, 2010 Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals ...
Beau J Fenner +2 more
doaj +1 more source
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]
, 2008 RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan +3 more
core +1 more source
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. [PDF]
PLoS ONE, 2009 The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis.Mice were fed a diet containing 0.5 and 2% TLE or
Young-Eun Joo +6 more
doaj +1 more source
RelB-dependent stromal cells promote T-cell leukemogenesis. [PDF]
PLoS ONE, 2008 BACKGROUND: The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to ...
Nuno R dos Santos +7 more
doaj +1 more source
Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. [PDF]
PLoS ONE, 2014 Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival.
Tamar Canello +5 more
doaj +1 more source