IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. [PDF]
PLoS ONE, 2010 Activation of the transcription factor NF-kappaB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkappaB proteins.
Mazhar Adli +3 more
doaj +1 more source
PLoS Pathogens, 2009 Nuclear factor (NF)-kappaB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kappaB occurs predominantly in the cytoplasm, where Tax1 binds NF-kappaB Essential Modulator (NEMO ...
Chloé Journo +11 more
doaj +1 more source
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. [PDF]
PLoS ONE, 2010 Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport.
Mairi J Hunter +5 more
doaj +1 more source
NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]
, 2011 NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela +20 more
core +1 more source
ICAM-1 expression is highly NF-kappaB-dependent in A549 cells. No role for ERK and p38 MAPK
, 2004 The transcription factor nuclear factor kappaB (NF-kappaB) is an activator of multiple cytokines, chemokines and adhesion molecules, which are important in inflammatory diseases such as asthma, and is consequently considered as an attractive therapeutic ...
Neil Holden (17160016) +4 more
core +5 more sources
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. [PDF]
PLoS ONE, 2007 The flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown.To address the therapeutic impact of luteolin, NF-kappaB(EGFP) transgenic mice were fed a chow
Thomas Karrasch +3 more
doaj +1 more source
Memory extinction entails the inhibition of the transcription factor NF-kappaB. [PDF]
PLoS ONE, 2008 In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation ...
Emiliano Merlo, Arturo Romano
doaj +1 more source
IKKα regulation of canonical NF-κB activation downstream of Nod1-mediated peptidoglycan recognition : "and" Endocytosis-independent function of clathrin heavy chain in the control of basal NF-κB activation [PDF]
, 2010 NF-κB is a transcription factor involved in the regulation of inflammation and innate immunity. The IκB kinase (IKK) complex contains two catalytic subunits, IKKα and IKKβ, and plays an essential role in the activation of NF-κB through the ...
Kim, Man Lyang
core +1 more source
Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]
, 2012 Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W. +11 more
core +2 more sources
, 2009 Acting via the glucocorticoid receptor (GR), glucocorticoids exert potent anti-inflammatory effects partly by repressing inflammatory gene transcription occurring via factors such as NF-kappaB.
Elizabeth M. King (8868191) +4 more
core +5 more sources