Results 41 to 50 of about 24,183 (134)

NF kappaB expression increases and CFTR and MUC1 expression decreases in the endometrium of infertile patients with hydrosalpinx: a comparative study

Reproductive Biology and Endocrinology, 2012
Background Hydrosalpinx are associated with infertility, due to reduced rates of implantation and increased abortion rates. The aims of this study were to investigate the expression of cystic fibrosis transmembrane conductance regulator (CFTR), nuclear ...
Song Yong, Wang Qiushi, Huang Wei, Xiao Li, Shen Licong, Xu Wenming   +5 more
doaj   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Dongjun Guo, Lirong Han, Nicholas R. Rensing, Laura A. Jansen, Michael Wong   +4 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome

Frontiers in Immunology, 2014
T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10 and MALT1, which is required for TCR ...
Lisa M Minter, Hyun Mu Shin, Mulualem E Tilahun, Ok Hyun Cho, Karthik eChandiran, Christina Arieta Kuksin, Shilpa eKeerthivasan, Abdul H Fauq, Abdul H Fauq, Todd E Golde, Lucio eMiele, Margot eThome, Barbara A Osborne, Barbara A Osborne   +13 more
doaj   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. [PDF]

PLoS ONE, 2009
BACKGROUND: Coenzyme Q (CoQ) is a lipophilic antioxidant that is synthesized by a mitochondrial complex integrated by at least ten nuclear encoded COQ gene products.
Gloria Brea-Calvo, Emilio Siendones, José A Sánchez-Alcázar, Rafael de Cabo, Plácido Navas   +4 more
doaj   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

PLoS ONE, 2010
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as a "death ligand"-a member of the TNF superfamily that binds to receptors bearing death domains.
Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux   +12 more
doaj   +1 more source