Results 61 to 70 of about 24,183 (134)

Role of poly (ADP-ribose) polymerase-1 and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals

Bangladesh Journal of Pharmacology, 2018
The objective of this study was to evaluate the role of poly (ADP-ribose) polymerase-1 (PARP-1) and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals (n=110) of either gender aged
Anguo Chen, Zaicheng Yu, Renquan Zhang, Qihong Zhao, Jianjun Ge   +4 more
doaj   +1 more source

The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells. [PDF]

PLoS ONE, 2010
BACKGROUND: In Bacillus anthracis, lethal toxin (LeTx) is a critical virulence factor that causes immune suppression and toxic shock in the infected host. NF-kappaB is a key mediator of the inflammatory response and is crucial for the plasticity of first
Nando Dulal Das, Kyoung Hwa Jung, Young Gyu Chai   +2 more
doaj   +1 more source

Sulfation Rewrites the Biological Profile of Dietary Flavonoids: Implications for Stability, Redox Signaling, and Inflammation

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Enzymatic sulfation of dietary flavonoids increases their stability while attenuating antioxidant activity, cytotoxicity, and NRF2 activation. Sulfated flavonoids remain biologically active, modulating inflammatory markers, and represent authentic human metabolites relevant for nutritional and metabolic studies.
Jiří Vrba, Veronika Zapletalová, Jakub Havlásek, Barbora Papoušková, Barbora Petránková, Helena Pelantová, Kateřina Valentová   +6 more
wiley   +1 more source

Exploring the Mechanism of Action of Danggui Buxue Decoction in Treating Chronic Glomerulonephritis Based on UPLC‐MS/MS and Network Pharmacology

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Ethnopharmacological Relevance According to Chinese medicine theory, chronic glomerulonephritis (CGN) is characterized by dampness‐heat and blood stasis. Danggui Buxue Decoction (DBD) has shown good efficacy in the treatment of diseases associated with qi deficiency and blood stasis (such as CGN).
Qiao Liu, Yinghang Wang, Xinyue Wang, Hongmei Yang, Zhi Pan, Di Guo   +5 more
wiley   +1 more source

TNF receptor associated factor 1 (TRAF1) is a major target of soluble TWEAK

Frontiers in Immunology, 2014
Soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), in contrast to membrane TWEAK and TNF, is only a weak activator of the classical NF-kappaB pathway. We observed that soluble TWEAK was regularly more potent than TNF with respect
José Antonio Carmona Arana, Axel eSeher, Manfred eNeumann, Isabell eLang, Daniela eSiegmund, Harald eWajant   +5 more
doaj   +1 more source

Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. [PDF]

PLoS ONE, 2009
BACKGROUND:Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo. Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (
Meng-Yen Li, Feng-Jie Lai, Li-Jin Hsu, Chen-Peng Lo, Ching-Li Cheng, Sing-Ru Lin, Ming-Hui Lee, Jean-Yun Chang, Dudekula Subhan, Ming-Shu Tsai, Chun-I Sze, Subbiah Pugazhenthi, Nan-Shan Chang, Shur-Tzu Chen   +13 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Molecular Cancer, 2012
Background Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer ...
Crone Stephanie, Jacobsen Anders, Federspiel Birgitte, Bardram Linda, Krogh Anders, Lund Anders H, Friis-Hansen Lennart   +6 more
doaj   +1 more source

Isocitrate Dehydrogenase (IDH) Mutations in Hematological Malignancies: Epidemiology, Mechanisms, and Therapeutic Strategies

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley   +1 more source

Clinical and molecular features of primary gliosarcoma with digital spatial whole‐transcriptome analysis of glial and mesenchymal components

Brain Pathology, Volume 36, Issue 5, September 2026.
We report the clinical and genetic features of an institutional cohort of primary adult gliosarcomas compared to glioblastoma. We performed spatial whole‐transcriptome analysis on glial and sarcomatous regions of four cases to compare gene expression profiles and validated differential protein expression for two markers in tissue sections.
Matthew D. Wood, Gabriel Zangirolani, Jinho Lee, Melanie H. Hakar, Tanaya Neff, Kevin Y. Zhang, Christopher L. Corless   +6 more
wiley   +1 more source