Results 61 to 70 of about 23,717 (182)
Biochemical pharmacology, 2001 Camptothecin (CPT) and derivatives are topoisomerase I poisons currently used as anticancer drugs. Their cytotoxicity is maximal for cells in S phase. Using asynchronous and S phase-synchronized HeLa cells, we showed that both the nuclear factor-kappaB (NF-kappaB) activation and its transcriptional activity, induced by CPT treatment, are enhanced in S ...
Habraken, Yvette +2 more
openaire +2 more sources
SIRT1: Protean roles at the nexus of health, disease, and therapeutics
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.SIRT1 serves as a central regulator linking metabolism, stress responses, and disease. It influences diverse processes, including transcriptional and posttranscriptional gene expression and protein activity, inflammation, mitochondrial function, and cell survival, through the deacetylation of multiple protein targets. While SIRT1 often plays protective
Brahim Chaqour
wiley +1 more source
Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia
Ecology and Evolution, Volume 16, Issue 6, June 2026.The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.This study provides a novel molecular perspective on the role of AS in ADs development. We identified a positive association between artificially sweetened cereal intake and ADs risk and revealed multiple pathogenic mechanisms involving apoptosis, inflammatory signaling, immune activation, and gut microbiota dysbiosis.
Yupei Liu +6 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Rofia Ali, Muhammad Faizan Khan
wiley +1 more source
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
TNF Superfamily: A Growing Saga of Kidney Injury Modulators
Mediators of Inflammation, 2010 Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury.
Maria D. Sanchez-Niño +11 more
doaj +1 more source
PLoS ONE, 2008 Astroglia are key cellular sites where opiate drug signals converge with the proinflammatory effects of HIV-1 Tat signals to exacerbate HIV encephalitis.
Nazira El-Hage +6 more
doaj +1 more source
Noncanonical NF-kappaB Signaling Is Limited by Classical NF-kappaB Activity.
, 2014 Precise regulation of nuclear factor kappaB (NF-kappaB) signaling is crucial for normal immune responses, and defective NF-kappaB activity underlies a range of immunodeficiencies. NF-kappaB is activated through two signaling cascades: the classical and noncanonical pathways.
Gray, Carolyn M. +6 more
openaire +1 more source
PLoS Pathogens, 2010 Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E.
Hayley J Newton +16 more
doaj +1 more source