Results 71 to 80 of about 24,183 (134)

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

Frontiers in Physiology, 2019
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the development of non-OA inflammatory disease. However, the precise involvement
He Zhang, Lu Ji, Yue Yang, Yingliang Wei, Xiaoning Zhang, Yi Gang, Jinghan Lu, Lunhao Bai   +7 more
doaj   +1 more source

Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppressors, influencing key cellular events such as cell growth, programmed cell death, neovascularization, tissue invasion, and ...
T. Jeethy Ram, Muralee Damodaran
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 357-374, August 2026.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

TNF Superfamily: A Growing Saga of Kidney Injury Modulators

Mediators of Inflammation, 2010
Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury.
Maria D. Sanchez-Niño, Alberto Benito-Martin, Sara Gonçalves, Ana B. Sanz, Alvaro C. Ucero, Maria C. Izquierdo, Adrian M. Ramos, Sergio Berzal, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz   +11 more
doaj   +1 more source

Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription.

PLoS ONE, 2008
Astroglia are key cellular sites where opiate drug signals converge with the proinflammatory effects of HIV-1 Tat signals to exacerbate HIV encephalitis.
Nazira El-Hage, Annadora J Bruce-Keller, Tatiana Yakovleva, Igor Bazov, Georgy Bakalkin, Pamela E Knapp, Kurt F Hauser   +6 more
doaj   +1 more source

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

PLoS Pathogens, 2010
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E.
Hayley J Newton, Jaclyn S Pearson, Luminita Badea, Michelle Kelly, Mark Lucas, Gavan Holloway, Kylie M Wagstaff, Michelle A Dunstone, Joan Sloan, James C Whisstock, James B Kaper, Roy M Robins-Browne, David A Jans, Gad Frankel, Alan D Phillips, Barbara S Coulson, Elizabeth L Hartland   +16 more
doaj   +1 more source

TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

Frontiers in Pharmacology, 2016
Tumor necrosis factor-alpha (TNF-alpha) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha induced cPLA2 expression were
Chih-Chung Lin, Wei Ning Lin, Rou-Ling Cho, Chen-yu Wang, Li-Der Hsiao, Chuen-Mao Yang, Chuen-Mao Yang, Chuen-Mao Yang   +7 more
doaj   +1 more source

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

PLoS ONE, 2009
BackgroundIn response to viral infection, the innate immune system recognizes viral nucleic acids and then induces production of proinflammatory cytokines and type I interferons (IFNs).
Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun-ichiro Inoue   +15 more
doaj   +1 more source

TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation. [PDF]

Immun Inflamm Dis, 2023
Qian X, Wang Y, Li X, Li Y, Li L.
europepmc   +1 more source

Intravenous Injection of PEI-Decorated Iron Oxide Nanoparticles Impacts NF-kappaB Protein Expression in Immunologically Stressed Mice. [PDF]

Nanomaterials (Basel), 2023
Schwarz C, Göring J, Grüttner C, Hilger I.   +3 more
europepmc   +1 more source