Results 91 to 100 of about 188,422 (163)

Cyclovirobuxine D suppresses cancer stemness in osteosarcoma with implication of the noncanonical NF-kappaB pathway

Frontiers in Pharmacology
BackgroundCyclovirobuxine D (CVB-D), an alkaloid from Buxus microphylla, exhibits anticancer effects in various tumors, but its role in osteosarcoma remains unexplored. This study investigates its efficacy and mechanism in osteosarcoma.MethodsWe screened
Jinku Guo, Yingfeng Cao, Kaipen Jin, Kaipen Jin, Kaipen Jin, Kaipen Jin, Bing Liu, Bing Liu, Bing Liu, Bing Liu, Wei Wang, Chen Chen, Chen Chen, Jun Xie, Ankai Xu   +14 more
doaj   +1 more source

Expression of CYLD, NF-kappaB and NF-kappaB-related factors in salivary gland tumors.

In vivo (Athens, Greece), 2006
The cylindromatosis (CYLD) gene was originally identified as a tumor suppressor that is mutated in familial cylindromatosis, an autosomal dominant condition that confers a predisposition to multiple tumors of the skin appendages. CYLD has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB.
Masakatsu, Fukuda, Fumie, Fukuda, Yuko, Horiuchi, Yuka, Oku, Seiji, Suzuki, Kaoru, Kusama, Hideaki, Sakashita   +6 more
openaire   +1 more source

TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

Frontiers in Pharmacology, 2016
Tumor necrosis factor-alpha (TNF-alpha) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha induced cPLA2 expression were
Chih-Chung Lin, Wei Ning Lin, Rou-Ling Cho, Chen-yu Wang, Li-Der Hsiao, Chuen-Mao Yang, Chuen-Mao Yang, Chuen-Mao Yang   +7 more
doaj   +1 more source

NF-kappaB and AP-1 Connection: Mechanism of NF-kappaB-Dependent Regulation of AP-1 Activity [PDF]

, 2004
Nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) transcription factors regulate many important biological and pathological processes. Activation of NF-kappaB is regulated by the inducible phosphorylation of NF-kappaB inhibitor IkappaB by ...
Abbruzzese, James L, Sclabas, Guido M, Li, Zhongkui, Fujioka, Shuichi, Chiao, Paul J, Uwagawa, Tadashi, Evans, Douglas B, Niu, Jiangong, Peng, Bailu, Schmidt, Christian   +9 more
core   +1 more source

NF-kappaB in solid tumors.

Biochemical pharmacology, 2006
Cancer is a multistep process during which cells acquire genetic alterations that drive the progressive transformation of normal cells into highly malignant cells. Self-sufficiency in growth, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis, are ...
Pacifico F, Leonardi A
openaire   +2 more sources

A method for isolating prosurvival targets of NF-kappaB/Rel transcription factors

, 2007
NF-KappaB/Rel transcription factors are critical regulators of immunity, inflammation, development, and cell survival. Activation of NF-KB inhibits programmed cell death (PCD) triggered by tumor necrosis factor alpha (TNFalpha) and several other stimuli.
BUBICI C, KNABB JR, KUNTZEN C, PHAM CG, ZAZZERONI, FRANCESCA, PAPA S, FRANZOSO G.   +6 more
core  

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol, Male, David K, Cerutti, Camilla, Michael, G.J., Dongsheng Wu, van der Pol, SM, Sharrack, B, Romero, I.A., Baker, D., Michael, Gregory J, Simpson, Julie E., Cerutti, C., Simpson, J.E., Lopez-Ramirez, Miguel A., David Baker, Romero, IA, Wu, D.S., de Vries, H.E., Baker, David, King-Robson, J., Basil Sharrack, Simpson, Julie E, Michael, GJ, Wu, Dongsheng, van der Pol, Susanne M A, Hirst, Mark C, Julie E Simpson, Ignacio A Romero, Pryce, Gareth, Baker, D, Gregory J Michael, de Vries, Helga E, Romero, Ignacio A., Hirst, MC, King-Robson, Josh, de Vries, HE, Lopez-Ramirez, Alejandro, Mark C Hirst, David K Male, Male, DK, de Vries, Helga E., Gareth Pryce, Josh King-Robson, Camilla Cerutti, van der Pol, SMA, Romero, Ignacio A, van der Pol, S.M.A., Lopez-Ramirez, Miguel A, Male, D.K., Male, David K., Sharrack, B., King-Robson, J, van der Pol, Susanne M. A., Wu, D, Simpson, JE, Lopez-Ramirez, MA, Miguel A Lopez-Ramirez, Hirst, M.C., van der Pol, Susanne Ma, Cerutti, C, Helga E de Vries, Pryce, G, Pryce, G., Hirst, Mark C., Sharrack, Basil, Michael, Gregory J., Lopez-Ramirez, M.A.   +66 more
core   +1 more source

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

PLoS ONE, 2009
BackgroundIn response to viral infection, the innate immune system recognizes viral nucleic acids and then induces production of proinflammatory cytokines and type I interferons (IFNs).
Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun-ichiro Inoue   +15 more
doaj   +1 more source

MOLECULAR MODELLING STUDIES OF THE NF-κB BIOLOGICAL SYSTEM AS RELEVANT DRUG TARGET

, 2009
Background Virtual screening (VS) is now a well-established method for finding small molecular modulators of a biological relevant macromolecule function by using much older computational techniques, such as docking simulations.
Piccagli, Laura
core  

At the crossroads of SUMO and NF-kappaB.

Molecular cancer, 2004
Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhesion molecules, depending on activation of various inducible transcription factors, among which the family NF-kappaB transcription factors plays ...
Martin P, Kracklauer, Christian, Schmidt
openaire   +1 more source