Results 101 to 110 of about 188,422 (163)

The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]

, 2008
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Kevin David, Lauren Mauro, Savita Bhalla, Sheila Prachand, Andrew Evens, Leo Gordon, Joseph Buggy, Sriram Balasubramanian, Mint Sirisawad, Richard Miller   +9 more
core  

Mechanisms of Non-canonical NF-kappaB Regulation [PDF]

, 2014
NF-kappaB is activated through two signaling cascades: the classical and non-canonical pathways, which are distinguished based on the Inhibitor of kappaB Kinase (IKK) components required to activate each pathway.
Gray, Carolyn Margaret
core  

Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites

, 2001
The decoy approach against nuclear factor kappaB (NF-kappaB) is a useful tool to alter NF-kappaB dependent gene expression using synthetic oligonucleotides (ODNs) carrying NF-kappaB specific cis-elements. Unfortunately, ODNs are not stable and need to be
SAVIANO M, BIANCHI N, MISCHIATI, Carlo, GAMBARI R., Romanelli A, PEDONE C, BIANCHI, Nicoletta, ROMANELLI, ALESSANDRA, MISCHIATI C, GAMBARI, Roberto, BORGATTI M, BORGATTI, Monica   +11 more
core  

NF-kappaB activation in sarcoidosis.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2001
Sarcoidosis is an inflammatory disorder of unknown origin. The nuclear regulatory factor-kappaB (NF-kappaB) appears to play a key role in immune and inflammatory processes such as asthma, rheumatoid arthritis and inflammatory bowel disease. We hypothesized that NF-kappaB activation might be involved in the pathological process of sarcoidosis.Twelve ...
Drent, M., van den Berg, R., Haenen, G.R.M.M., van den Berg, H., Wouters, E.F.M., Bast, A.   +5 more
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

NF-kappaB and reperfusion injury

Drug News & Perspectives, 2004
This review discusses the current understanding of mechanisms that mediate activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and how such activation could in turn mediate reperfusion injury. NF-kappaB regulates the expression of several genes involved in inflammation, the immune response, apoptosis, cell survival and ...
openaire   +2 more sources

NF-kappaB-inducing kinase in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2019
Dysregulation of the alternative NF-κB signaling has severe developmental consequences that can ultimately lead to oncogenesis. Pivotal for the activation of the alternative NF-κB pathway is the stabilization of the NF-κB-inducing kinase (NIK). The aim of this review is to focus on the emerging role of NIK in cancer. The documented subversion of NIK in
Gunter Maubach, Michael H. Feige, Michelle C.C. Lim, Michael Naumann   +3 more
openaire   +2 more sources

Expression of NF-kappaB in epidermis and the relationship between NF-kappaB activation and inhibition of keratinocyte growth

British Journal of Dermatology, 2003
Nuclear factor-kappaB (NF-kappaB) is a transcription factor involved in a number of signalling pathways in many cell types. NF-kappaB in mice has been implicated as an important regulator of keratinocyte proliferation and differentiation.To evaluate the role of NF-kappaB in keratinocyte growth in human beings, we examined its expression in ...
J, Takao, T, Yudate, A, Das, S, Shikano, M, Bonkobara, K, Ariizumi, P D, Cruz   +6 more
openaire   +2 more sources

NF-kappaB in renal inflammation.

Journal of the American Society of Nephrology : JASN, 2010
The NF-kappaB family of transcription factors regulates the induction and resolution of inflammation. Two main pathways, classical and alternative, control the nuclear translocation of NF-kappaB. Classical NF-kappaB activation is usually a rapid and transient response to a wide range of stimuli whose main effector is RelA/p50. The alternative NF-kappaB
Ana Belen, Sanz, Maria Dolores, Sanchez-Niño, Adrian Mario, Ramos, Juan Antonio, Moreno, Beatriz, Santamaria, Marta, Ruiz-Ortega, Jesus, Egido, Alberto, Ortiz   +7 more
openaire   +2 more sources

Signaling to NF-kappaB.

Genes & development, 2004
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood.
Matthew S, Hayden, Sankar, Ghosh
openaire   +1 more source

NF-kappaB and cytokines.

Vitamins and hormones, 2006
Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-kappaB (NF-kappaB). NF-kappaB is a ubiquitous transcription factor which is crucially involved in many biological
Dagmar, Kulms, Thomas, Schwarz
openaire   +1 more source