Results 131 to 140 of about 23,717 (182)
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Vitamins and hormones, 2006
Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-kappaB (NF-kappaB). NF-kappaB is a ubiquitous transcription factor which is crucially involved in many biological
Dagmar, Kulms, Thomas, Schwarz
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Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-kappaB (NF-kappaB). NF-kappaB is a ubiquitous transcription factor which is crucially involved in many biological
Dagmar, Kulms, Thomas, Schwarz
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Regulation of the gadd45beta promoter by NF-kappaB.
DNA and cell biology, 2002In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. The NF-kappaB antiapoptotic function is crucial to oncogenesis, cancer chemoresistance, and to antagonize tumor necrosis factor (TNF) receptor-induced killing.
JIN R +8 more
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International journal of oncology, 2007
Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival. This review summarizes our understanding of the potentially important role of inflammation in cancer in general and pancreatic cancer in particular.
Zhiquan, Zhang, Basil, Rigas
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Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival. This review summarizes our understanding of the potentially important role of inflammation in cancer in general and pancreatic cancer in particular.
Zhiquan, Zhang, Basil, Rigas
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Critical care medicine, 2000
Binding sites for the transcriptional regulatory factor nuclear factor kappa B (NF-kappaB) are present in the promoter regions of many of the proinflammatory cytokines and immunoregulatory mediators important in inducing acute inflammatory responses associated with critical illnesses.
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Binding sites for the transcriptional regulatory factor nuclear factor kappa B (NF-kappaB) are present in the promoter regions of many of the proinflammatory cytokines and immunoregulatory mediators important in inducing acute inflammatory responses associated with critical illnesses.
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NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach.
Annals of the New York Academy of Sciences, 2006The transcription factor, nuclear factor-kappaB (NF-kappaB), is a dominant regulator of the expression of hundreds of genes, many of which play important roles in the regulation of inflammation and programmed cell death (apoptosis). Since the discovery of NF-kappaB in the mid 1980s, this transcription factor has been the subject of intense ...
Laurence J, Egan, Murat, Toruner
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Cold Spring Harbor perspectives in biology, 2010
David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.
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David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.
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Molecular cell, 2002
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune ...
Joel L, Pomerantz, David, Baltimore
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NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune ...
Joel L, Pomerantz, David, Baltimore
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NF-kappaB in pancreatic cancer.
International journal of gastrointestinal cancer, 2004Although the genetic profile of pancreatic cancer is emerging as a result of much research, the role of specific genetic alterations that initiate tumorigenesis and produce its cardinal clinical features of locally aggressive growth, metastasis, and chemotherapy resistance remains unresolved. Recently, a number of studies have shown that the inhibition
Guido M, Sclabas +4 more
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Cell, 1999
IkappaBalpha regulates the transcription factor NF-kappaB through the formation of stable IkappaBalpha/NF-kappaB complexes. Prior to induction, IkappaBalpha retains NF-kappaB in the cytoplasm until the NF-kappaB activation signal is received. After activation, NF-kappaB is removed from gene promoters through association with nuclear IkappaBalpha ...
T, Huxford +3 more
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IkappaBalpha regulates the transcription factor NF-kappaB through the formation of stable IkappaBalpha/NF-kappaB complexes. Prior to induction, IkappaBalpha retains NF-kappaB in the cytoplasm until the NF-kappaB activation signal is received. After activation, NF-kappaB is removed from gene promoters through association with nuclear IkappaBalpha ...
T, Huxford +3 more
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NF-kappaB activation in melanoma.
Pigment cell research, 2006Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappaB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappaB, (ii ...
Yukiko, Ueda, Ann, Richmond
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