Results 51 to 60 of about 24,183 (134)

Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. [PDF]

PLoS ONE, 2007
Non-typeable Haemophilus influenza (NTHi) is an important human pathogen causing respiratory tract infections in both adults and children. NTHi infections are characterized by inflammation, which is mainly mediated by nuclear transcription factor kappaB (
Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Chang-Hoon Woo, Hajime Ishinaga, Patricia Bourne, Haodong Xu, Un-Hwan Ha, Haidong Xu, Jian-Dong Li   +9 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis

Haematologica, 2006
Since nuclear factor-kappaB (NF-kappaB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-kappaB can affect the cellular properties of cord blood CD34+ cells.
H Schepers, BJ Eggen, JJ Schuringa, E Vellenga   +3 more
doaj  

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway

BMC Cancer, 2012
Background The prognosis of human glioma is poor, and the highly invasive nature of the disease represents a major impediment to current therapeutic modalities. The oncoprotein B-cell-specific Moloney murine leukemia virus integration site 1 protein (Bmi-
Jiang Lili, Wu Jueheng, Yang Yi, Liu Liping, Song Libing, Li Jun, Li Mengfeng   +6 more
doaj   +1 more source

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. [PDF]

PLoS ONE, 2009
Transcription of the mast cell growth factor SCF (stem cell factor) is upregulated in inflammatory conditions, and this is dependent upon NF-kappaB, as well as the MAP kinases p38 and ERK activation.
Laurent Reber, Linda Vermeulen, Guy Haegeman, Nelly Frossard   +3 more
doaj   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 4, Page 926-936, October 2026.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel, Çilem Özdemir, Tuba Edgünlü, Ozan Gökdoğan   +3 more
wiley   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, Volume 59, Issue 10, October 2026.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of Rubus chingii Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Experimental flow chart of the attenuating and synergistic effects of RCH on TGTs in the treatment of rheumatoid arthritis. ABSTRACT Tripterygium Glycoside Tablets (TGTs) are primary drugs for rheumatoid arthritis (RA) but pose a risk of nephrotoxicity. Rubus chingii Hu (RCH) may enhance kidney function.
Cong Zhang, Zepeng Zhang, Fang Yan, Lei Zhang   +3 more
wiley   +1 more source