Results 51 to 60 of about 577,005 (273)

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease? [PDF]

Frontiers in Molecular Neuroscience, 2015
Alzheimer’s disease (AD) is a neurodegenerative disorder that impacts the daily lives of many sufferers throughmemory loss as well as behavioral and cognitive changes. AD is themost common form of dementia. One in ten people over the age of 65, and around half of those over 85 have AD.
Karunaweera, Niloo (S31677), Raju, Ritesh (R17740), Gyengesi, Erika (R17270), Muench, Gerald (R12224)   +3 more
openaire   +3 more sources

The Ubiquitination of NF-κB Subunits in the Control of Transcription

Cells, 2016
Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB ...
Patricia E. Collins, Izaskun Mitxitorena, Ruaidhrí J. Carmody   +2 more
doaj   +1 more source

Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching

Scientific Reports, 2017
Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-
Katelyn M. Mansfield, Nicole M. Carter, Linda Nguyen, Phillip A. Cleves, Anar Alshanbayeva, Leah M. Williams, Camerron Crowder, Ashley R. Penvose, John R. Finnerty, Virginia M. Weis, Trevor W. Siggers, Thomas D. Gilmore   +11 more
doaj   +1 more source

Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells [PDF]

FEMS Immunology & Medical Microbiology, 2007
Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity. Glucocorticoids, on the other hand, exert immunosuppressive and anti-inflammatory actions. We have previously reported that interleukin (IL)-1beta induces HBD-2 mRNA expression through the activation of nuclear factor-kappaB (NF-kappaB ...
Byeong-Churl Jang, Ki-Jo Lim, Min-Ho Suh, Jong-Gu Park, Seong-Il Suh   +4 more
openaire   +3 more sources

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo

Journal of International Medical Research, 2018
Background To investigate the relationship between the levels of nuclear factor (NF)-κB p50 and NF-κB p65 and tumour characteristics in patients with thyroid carcinoma.
Fei Le, Jing-Yu Zhang, Wei Liu, Xian-Ming Huang, Wen-Zheng Luo   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

MOESM1 of Amentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF-κB pathways

, 2019
Additional file 1. Assessment of inflammation due to cold stress.
Cai, Jiayi, Zhao, Chunyang, Du, Yajie, Huang, Yuan, Zhao, Qingchun   +4 more
openaire   +1 more source

Risk stratification of patients with diffuse large B-cell lymphoma using plasma NMR-based metabolomics at diagnosis

Blood Advances
: Early detection of ultrahigh-risk diffuse large B-cell lymphoma (DLBCL) is an unmet medical need to aid patient stratification for alternative treatment approaches.
Aurélie Montagne, Gildas Bertho, Thomas Papastergiou, Loïc Chartier, Romain Ricci, Fabrice Jardin, Hervé Ghesquières, Cédric Rossi, Franck Morschhauser, Corinne Haioun, Vincent Ribrag, Pierre Feugier, Gabriel Brisou, Lucie Oberic, Philippe Gaulard, Nicolas Giraud, Younès Bennani, Catherine Thieblemont, Véronique Baud   +18 more
doaj   +1 more source

Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

Journal of Neuroinflammation, 2019
Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood ...
Thomas Taetzsch, Savannah Benusa, Shannon Levesque, Christen L. Mumaw, Michelle L. Block   +4 more
doaj   +1 more source

Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma [PDF]

, 2021
Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival.
Albadrani, Ghadeer M, Bin Emran, Talha, Abdullah Al Mamun, Alanazi, Ibtesam S, Ghadeer M. Albadrani, Ibtesam S. Alanazi, Nasrin, Fatema, Talha Bin Emran, Kabir, Md Tanvir, Amany A. Sayed, Rauf, Abdur, Al Mamun, Abdullah, Mousa, Shaker A, Shaker A. Mousa, Fatema Nasrin, Sarwar, Md Shahid, Abdur Rauf, Md. Sahab Uddin, Mohamed M. Abdel-Daim, Md. Tanvir Kabir, Sayed, Amany A, Md. Shahid Sarwar, Uddin, Md Sahab, Abdel-Daim, Mohamed M   +23 more
core   +1 more source