Results 51 to 60 of about 548,906 (279)

Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

Journal of Neuroinflammation, 2019
Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood ...
Thomas Taetzsch, Savannah Benusa, Shannon Levesque, Christen L. Mumaw, Michelle L. Block   +4 more
doaj   +1 more source

CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]

, 2019
The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad, DiRusso, Christopher J., Gilmore, Thomas D., Kagermazova, Larisa, Liu, Yuekun, McCaslin, Ethan Z., Miyamoto, Shigeki, Wuerzberger-Davis, Shelly M., Yeo, Alan T.   +8 more
core   +1 more source

Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway

Cellular and Molecular Biology, 2019
To investigate the effect of gentiopicrin on the expressions of inflammatory factors in human fibroblast-like synoviocytes (HFLS) and the underlying mechanism. Human fibroblast-like synoviocytes (HFLS) were cultured in vitro at 37 °C in Dulbecco's modified Eagle's medium (DMEM) supplemented with 5 % fetal bovine serum (FBS) in a humidified incubator ...
Nian, Zhang, Yi, Jiang, Fangxiang, Mu, Hong, Wu, Qingxia, You   +4 more
openaire   +3 more sources

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo

Journal of International Medical Research, 2018
Background To investigate the relationship between the levels of nuclear factor (NF)-κB p50 and NF-κB p65 and tumour characteristics in patients with thyroid carcinoma.
Fei Le, Jing-Yu Zhang, Wei Liu, Xian-Ming Huang, Wen-Zheng Luo   +4 more
doaj   +1 more source

CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]

, 2018
The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad, Gilmore, Thomas, Kagermazova, Larisa, Liu, Yuekun, Mccaslin, Ethan, Miyamoto, Shigeki, Wuerzberger-Davis, Shelly, Yeo, Alan   +7 more
core   +1 more source

A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB [PDF]

Frontiers in Immunology, 2014
The mammalian tumor necrosis factor (TNF) cytokine is a central mediator of inflammatory events. Recent studies revealed a number of complex and sophisticated interactions between the TNF pathway and the enzymatic activities encoded by ubiquitin ligases and deubiquitylation enzymes.
Brittany eFraser, Brittany eFraser, Robert A Maranchuk, Robert A Maranchuk, Edan eFoley, Edan eFoley   +5 more
openaire   +3 more sources

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon   +10 more
doaj   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis [PDF]

Cell Death & Differentiation, 2011
The ubiquitin-editing enzyme A20 (tumor necrosis factor-α-induced protein 3) serves as a critical brake on nuclear factor κB (NF-κB) signaling. In humans, polymorphisms in or near the A20 gene are associated with several inflammatory disorders, including psoriasis.
Declercq, Wim, Lippens, Saskia, Lefebvre, Sylvie, Gilbert, Barbara, Sze, Mozes, Devos, Michael, Vereecke, Lars, Mcguire, Conor, Guerin, Christopher J., Vandenabeele, Peter, Pasparakis, Manolis, Mikkola, Marja L, Beyaert, Rudi, van Loo, Geert, Verhelst, Kelly   +14 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source