Results 61 to 70 of about 548,906 (279)

Risk stratification of patients with diffuse large B-cell lymphoma using plasma NMR-based metabolomics at diagnosis

Blood Advances
: Early detection of ultrahigh-risk diffuse large B-cell lymphoma (DLBCL) is an unmet medical need to aid patient stratification for alternative treatment approaches.
Aurélie Montagne, Gildas Bertho, Thomas Papastergiou, Loïc Chartier, Romain Ricci, Fabrice Jardin, Hervé Ghesquières, Cédric Rossi, Franck Morschhauser, Corinne Haioun, Vincent Ribrag, Pierre Feugier, Gabriel Brisou, Lucie Oberic, Philippe Gaulard, Nicolas Giraud, Younès Bennani, Catherine Thieblemont, Véronique Baud   +18 more
doaj   +1 more source

MOESM1 of Amentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF-κB pathways

, 2019
Additional file 1. Assessment of inflammation due to cold stress.
Cai, Jiayi, Zhao, Chunyang, Du, Yajie, Huang, Yuan, Zhao, Qingchun   +4 more
openaire   +1 more source

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

International Journal of Molecular Medicine, 2011
Several kinds of sesquiterpene lactones have been proven to inhibit NF-κB and to retard atherosclerosis by reducing lesion size and changing plaque composition. The anti-malarial artemisinin (Art) is a pure sesquiterpene lactone extracted from the Chinese herb Artemisia annua (qinghao, sweet wormwood).
Yue, Wang, Zhouqing, Huang, Liansheng, Wang, Shu, Meng, Yuqi, Fan, Ting, Chen, Jiatian, Cao, Rujia, Jiang, Changqian, Wang   +8 more
openaire   +3 more sources

Modulation of NF-κB activation inTheileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]

Cellular Microbiology, 2010
Apicomplexan parasites within the genus Theileria have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte. Protection against apoptosis involves constitutive activation of the bovine transcription factor NF-kappaB in a parasite-dependent manner. Activation of NF-kappaB is thought to involve recruitment
Schmuckli-Maurer, J., Kinnaird, J., Pillai, S., Hermann, P., McKellar, S., Weir, W., Dobbelaere, D., Shiels, B.   +7 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Constitutive activation of NF-κB in human hepatocellular carcinoma: Evidence of a cytoprotective role [PDF]

, 1992
Activation of nuclear factor-κB (NF-κB) can promote or inhibit apoptosis. Oxidative stress is an important mechanism by which certain anticancer drugs kill cancer cells, and is also one of the mechanisms that activate NF-κB. We therefore examined hepatic
Francisco, R, Zhang, H, Dent, P, Ebert, MPA, Röcken, C, Farrell, G, Yu, J, Qiao, L   +7 more
core   +4 more sources

Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells

Cell Death and Disease
Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and ...
Marcus K. Preedy, Michael R. H. White, Vinay Tergaonkar   +2 more
doaj   +1 more source

Involvement of Hormone Receptors, Membrane Receptors and Signaling Pathways in European Gastric Cancers Regarding Subtypes and Epigenetic Alterations: A Pilot Study

Biomedicines
Background: Gastric cancer (GC) is a highly heterogeneous disease and remains one of the major causes of cancer-related mortality worldwide. The vast majority of GC cases are adenocarcinomas including diffuse and intestinal GC that may differ in their ...
Cynthia Pimpie, Anne Schninzler, Marc Pocard, Véronique Baud, Martine Perrot-Applanat   +4 more
doaj   +1 more source

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy. [PDF]

PLoS ONE, 2015
NF-κB is a major inflammatory response mediator in the liver, playing a key role in the pathogenesis of alcoholic liver injury. We investigated zonal as well as liver cell type-specific distribution of NF-κB activation across the liver acinus following ...
Harshavardhan Nilakantan, Lakshmi Kuttippurathu, Austin Parrish, Jan B Hoek, Rajanikanth Vadigepalli   +4 more
doaj   +1 more source

New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks

Biology, 2023
The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation.
Dominga Iacobazzi, Paolo Convertini, Simona Todisco, Anna Santarsiero, Vito Iacobazzi, Vittoria Infantino   +5 more
doaj   +1 more source