Results 81 to 90 of about 525,635 (287)

Modulation of NF-κB activation inTheileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton [PDF]

Cellular Microbiology, 2010
Apicomplexan parasites within the genus Theileria have the ability to induce continuous proliferation and prevent apoptosis of the infected bovine leukocyte. Protection against apoptosis involves constitutive activation of the bovine transcription factor NF-kappaB in a parasite-dependent manner. Activation of NF-kappaB is thought to involve recruitment
Schmuckli-Maurer, J., Kinnaird, J., Pillai, S., Hermann, P., McKellar, S., Weir, W., Dobbelaere, D., Shiels, B.   +7 more
openaire   +4 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. [PDF]

PLoS ONE, 2012
TNF induced nuclear factor kappa B (NF-κB) is one of the central signaling pathways that plays a critical role in carcinogenesis and inflammatory diseases.
Dhanendra Tomar, Lakshmi Sripada, Paresh Prajapati, Rochika Singh, Arun Kumar Singh, Rajesh Singh   +5 more
doaj   +1 more source

Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling

Oncotarget, 2017
In this study, we investigated the roles of reactive oxygen species (ROS) and nuclear factor-κB (NF-κB) signaling in sodium fluoride-induced DNA damage and apoptosis in mouse splenocytes. Intragastric administration of 12, 24 or 48 mg/kg sodium fluoride resulted in a time- and dose-dependent increase in DNA fragmentation and apoptosis in mouse ...
Deng, Huidan, Kuang, Ping, Cui, Hengmin, Luo, Qin, Liu, Huan, Lu, Yujiao, Fang, Jing, Zuo, Zhicai, Deng, Junliang, Li, Yinglun, Wang, Xun, Zhao, Ling   +11 more
openaire   +3 more sources

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome [PDF]

Frontiers in Immunology, 2014
T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10, and MALT1, which is required for TCR-mediated NF-κB activation.
Lisa M Minter, Hyun Mu Shin, Mulualem E Tilahun, Ok Hyun Cho, Karthik eChandiran, Christina Arieta Kuksin, Shilpa eKeerthivasan, Abdul H Fauq, Abdul H Fauq, Todd E Golde, Lucio eMiele, Margot eThome, Barbara A Osborne, Barbara A Osborne   +13 more
openaire   +6 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]

, 2008
A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Hong Yue, Jianfang Jia, Yue, H., Jia, J.F., Yue, Hong, Jia, Jianfang   +5 more
core   +1 more source

Comparison of activities of transcription factor NF-κB from two jellyfish models

Comparative Immunology Reports
Herein, transcription factor Nuclear Factor-kappaB (NF-κB) is characterized as the downstream effector of putative innate immune signaling pathways from two model jellyfish, Aurelia aurita (Aa) and Clytia hemisphaerica (Ch). Both jellyfish NF-κB proteins
Leah M. Williams, Wei Wang, Alexandra V. Grigoryeva, Alejandra Navarro-Rosado, Jada A. Peart, Angela Calderon, Catherine L. Gill, Susan Black, Kristina M. Alsante, Aidan T. Lackstrom, Molecular Biology Laboratory, Brandon Weissbourd, Mengrui Wang, Christopher J. DiRusso, Lianne B. Cohen, Zeba Wunderlich, Brian P. Grone, Thomas D. Gilmore   +17 more
doaj   +1 more source

The N terminus of orf virus-encoded protein 002 inhibits acetylation of NF-κB p65 by preventing Ser(276) phosphorylation.

PLoS ONE, 2013
Orf virus-encoded protein 002 (ORFV002) inhibits NF-κB signaling pathway by decreasing the acetylation of NF-κB-p65 through interference of NF-κB p65's association with NF-κB p300.
Zhangyong Ning, Zewei Zheng, Wenbo Hao, Chaohui Duan, Wei Li, Yuanyuan Wang, Ming Li, Shuhong Luo   +7 more
doaj   +1 more source

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

International Journal of Molecular Medicine, 2011
Several kinds of sesquiterpene lactones have been proven to inhibit NF-κB and to retard atherosclerosis by reducing lesion size and changing plaque composition. The anti-malarial artemisinin (Art) is a pure sesquiterpene lactone extracted from the Chinese herb Artemisia annua (qinghao, sweet wormwood).
Yue, Wang, Zhouqing, Huang, Liansheng, Wang, Shu, Meng, Yuqi, Fan, Ting, Chen, Jiatian, Cao, Rujia, Jiang, Changqian, Wang   +8 more
openaire   +3 more sources