Results 101 to 110 of about 525,635 (287)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

NF-κB regulates the effect of rosuvastatin’s rescue of the CD40L stimulated P4Hα1 inhibition in CD40L-stimulated HASMCs. [PDF]

, 2016
(A and B) Representative images of NF-κb nuclear translocation and NF-κB DNA binding activity after treated with 5 μg/ml rhsCD40L for 0, 15, 30, 60 and 120 min by immunofluorescence (A) and EMSA (B).
Wei Sun (93580), Xiao-Lin Wang (1814713), Yuan-Li Zhou (2634259), Li Li (14993)   +3 more
core   +1 more source

Efficacy of herb-partitioned moxibustion at Qihai (CV 6) and bilateral Tianshu (ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn's disease

Journal of Traditional Chinese Medicine, 2018
To observe the effect of stimulating Qihai (CV 6) and bilateral Tianshu (ST 25) with herb-partitioned moxibustion (HPM) in rats with Crohn's disease (CD), and to investigate the possible anti-inflammatory mechanism of HPM.Forty rats were randomly divided into four groups (n = 10 rats per group): normal control (NC), model control (MC), mesalamine (MES),
Dan, Zhang, Xiaopeng, Ma, Huangan, Wu, Jue, Hong, Cuihong, Zhang, Lingxiang, Wu, Jie, Liu, Yi, Zhu, Ling, Yang, Kai, Wei, Huang, Yan   +10 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

PD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma.

OncoTargets and therapy, 2019
The aim of this study was to investigate the influence of epithelial-mesenchymal transition (EMT) occurring in gastric carcinoma cells and the involvement of programmed death ligand 1 (PD-L1) expression in tumor cells that undergo EMT. The mechanisms underlying PD-L1 expression during EMT in gastric carcinoma cells were also explored.The capacities of ...
Xu,Dan, Li,Jing, Li,Ruiyang, Lan,Ting, Xiao,Chi, Gong,Ping   +5 more
openaire   +3 more sources

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

PLoS ONE, 2012
Published by PLoS [u.a.], Lawrence, Kan.
Glas, Jürgen, Seiderer, Julia, Czamara, Darina, Pasciuto, Giulia, Diegelmann, Julia, Wetzke, Martin, Olszak, Torsten, Wolf, Christiane, Müller-Myhsok, Bertram, Balschun, Tobias, Achkar, Jean-Paul, Kamboh, M. Ilyas, Franke, Andre, Duerr, Richard H., Brand, Stephan   +14 more
openaire   +8 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patientswith esophageal squamous cell carcinoma

Pakistan Journal of Medical Sciences, 2014
Objective: To study the relationship between TLR4 and NF-?B p65 protein expressions in tumor tissues after radiotherapy and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.Methods: A total of 93 patients with esophageal squamous cell carcinoma first treated in our hospital by radiotherapy and surgeries from November 2010 ...
Tang, Hua, Wang, Feng, Zhou, Xi-Fa, Zhou, Jian, Chen, Ling, Luo, Ju-Dong, Xu, En-Ci   +6 more
openaire   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

NF-kappaB signaling pathways in Neurological inflammation: A mini review

Frontiers in Molecular Neuroscience, 2015
The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism for the cells in response to a wide variety of stimuli linking to ...
Ruey-Horng eShih, Chen -Yu eWang, Chuen-Mao eYang   +2 more
doaj   +1 more source