Results 101 to 110 of about 548,906 (279)

Efficacy of herb-partitioned moxibustion at Qihai (CV 6) and bilateral Tianshu (ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn's disease

Journal of Traditional Chinese Medicine, 2018
To observe the effect of stimulating Qihai (CV 6) and bilateral Tianshu (ST 25) with herb-partitioned moxibustion (HPM) in rats with Crohn's disease (CD), and to investigate the possible anti-inflammatory mechanism of HPM.Forty rats were randomly divided into four groups (n = 10 rats per group): normal control (NC), model control (MC), mesalamine (MES),
Dan, Zhang, Xiaopeng, Ma, Huangan, Wu, Jue, Hong, Cuihong, Zhang, Lingxiang, Wu, Jie, Liu, Yi, Zhu, Ling, Yang, Kai, Wei, Huang, Yan   +10 more
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB.

PLoS ONE, 2022
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers.
Katharine L Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A Houck, J Christopher Corton   +5 more
doaj   +1 more source

Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. [PDF]

, 2014
Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease, and, therefore, can be effective therapeutic targets. Neurotropin® (NTP) is a drug widely used in Japan and China to treat chronic pain.
Liang, Shuang, Liu, Cheng, Masuda, Koichi, Naiki, Mitsuru, Roh, Yoon Seok, Seki, Ekihiro, Zhang, Bi   +6 more
core   +3 more sources

IKKα regulation of canonical NF-κB activation downstream of Nod1-mediated peptidoglycan recognition : "and" Endocytosis-independent function of clathrin heavy chain in the control of basal NF-κB activation

, 2010
NF-κB is a transcription factor involved in the regulation of inflammation and innate immunity. The IκB kinase (IKK) complex contains two catalytic subunits, IKKα and IKKβ, and plays an essential role in the activation of NF-κB through the phosphorylation and degradation of the NF-κB inhibitor IκBα, thereby allowing translocation of NF-κB into the ...
openaire   +3 more sources

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

PLoS ONE, 2012
Published by PLoS [u.a.], Lawrence, Kan.
Glas, Jürgen, Seiderer, Julia, Czamara, Darina, Pasciuto, Giulia, Diegelmann, Julia, Wetzke, Martin, Olszak, Torsten, Wolf, Christiane, Müller-Myhsok, Bertram, Balschun, Tobias, Achkar, Jean-Paul, Kamboh, M. Ilyas, Franke, Andre, Duerr, Richard H., Brand, Stephan   +14 more
openaire   +7 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Chronic inflammation is the main mechanism responsible for liver fibrosis. NF-κB regulates inflammation, wound healing, and cell death. Curcumin acts as an antiinflammatory, antifibrotic and induced apoptosis, one of them through resistance
Supriono, Bogi Pratomo, Dedy Indra Praja
doaj   +1 more source

PD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma.

OncoTargets and therapy, 2019
The aim of this study was to investigate the influence of epithelial-mesenchymal transition (EMT) occurring in gastric carcinoma cells and the involvement of programmed death ligand 1 (PD-L1) expression in tumor cells that undergo EMT. The mechanisms underlying PD-L1 expression during EMT in gastric carcinoma cells were also explored.The capacities of ...
Xu,Dan, Li,Jing, Li,Ruiyang, Lan,Ting, Xiao,Chi, Gong,Ping   +5 more
openaire   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source