Results 91 to 100 of about 495,858 (236)
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons
, 2013 Klenke C, Widera D, Engelen T, et al. Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 2013;8(6): e65280.Signaling via NF-κB in neurons depends on complex formation with interactors such as dynein/dynactin motor ...
Klenke, Christin +30 more
core +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
, 2009 Summary Onion powder has been reported to decrease the ovariectomy-induced bone resorption of rats. However, the molecular mechanism of onion powder on the bone cells has not been reported.
湯智昕;符文美;楊榮森 +1 more
core
, 2016 Immunofluorescence (IF) staining of phospho-NF-κB (p-p65 S529) is demonstrated in (A) HHK and (B) HHPC treated by 0.1 mg/ml pepsin at different pH (acid, pH 4.0; weakly acidic, pH 5.0 and neutral, pH 7.0) and corresponding controls. Acidic-pepsin treated
Julia Toman (3545372) +2 more
core +1 more source
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]
, 2013 Hypoxia-inducible factor is a key transcriptional factor involved in the cellular response to low levels of oxygen, hypoxia. Moreover, hypoxia-inducible factor has been recently associated with a role in inflammation and immunity.
Rocha, S., Bandarra, D.
core
NF-κB regulates gTlr9 alternative splicing.
, 2016 Two inhibitors BAY and SR, which targeted either NF-κB or AP-1 transcription factors, respectively, were applied under CpG ODN stimulation. The inhibition of one transcription factor under stimulation would result in activation of the other (see text for
Tien-Hsien Chang (112560) +3 more
core +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
NF-κB regulates neuronal ankyrin-G via a negative feedback loop.
, 2017 The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation ...
Jochen Prehn (7895672) +6 more
core +2 more sources