Results 71 to 80 of about 577,005 (273)

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

Viruses, 2018
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream molecules, which include receptors, adaptor proteins, NF-κB (IκB ...
Liyao Deng, Qiurui Zeng, Mingshu Wang, Anchun Cheng, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen   +15 more
doaj   +1 more source

Modulation of granulocyte-endothelium interactions by antileukoproteinase : inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium [PDF]

, 2006
Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity.
Rikard Holmdahl, Kutty Nandakumar, Vollmar, Brigitte,, Sehnert, Bettina,, Harald Burkhardt, Rupert Hallmann, Hallmann, Rupert,, Anja Kühl, Reinhard Voll, Ibrahim, Saleh, Nandakumar, Kutty Selva,, Holmdahl, Rikard, Voll, Reinhard,, Burkhardt, Harald,, Gierer, Philip,, Bettina Sehnert, Burkhardt, Harald, Hallmann, Rupert, Saleh Ibrahim, Nandakumar, Kutty Selva, Vollmar, Brigitte, Ibrahim, Saleh,, Kühl, Anja,, Kuehl, Anja, Sehnert, Bettina, Philip Gierer, Gierer, Philip, Kühl, Anja, Lund University., Voll, Reinhard, Holmdahl, Rikard,, Brigitte Vollmar   +31 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB [PDF]

Frontiers in Immunology, 2014
The mammalian tumor necrosis factor (TNF) cytokine is a central mediator of inflammatory events. Recent studies revealed a number of complex and sophisticated interactions between the TNF pathway and the enzymatic activities encoded by ubiquitin ligases and deubiquitylation enzymes.
Brittany eFraser, Brittany eFraser, Robert A Maranchuk, Robert A Maranchuk, Edan eFoley, Edan eFoley   +5 more
openaire   +3 more sources

The NF-κB Genomic Landscape in Lymphoblastoid B Cells

Cell Reports, 2014
The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B cell development and function. To systematically characterize their responses to canonical and noncanonical NF-κB pathway activity, we performed chromatin ...
Bo Zhao, Luis A. Barrera, Ina Ersing, Bradford Willox, Stefanie C.S. Schmidt, Hannah Greenfeld, Hufeng Zhou, Sarah B. Mollo, Tommy T. Shi, Kaoru Takasaki, Sizun Jiang, Ellen Cahir-McFarland, Manolis Kellis, Martha L. Bulyk, Elliott Kieff, Benjamin E. Gewurz   +15 more
doaj   +1 more source

Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. [PDF]

PLoS ONE, 2012
TNF induced nuclear factor kappa B (NF-κB) is one of the central signaling pathways that plays a critical role in carcinogenesis and inflammatory diseases.
Dhanendra Tomar, Lakshmi Sripada, Paresh Prajapati, Rochika Singh, Arun Kumar Singh, Rajesh Singh   +5 more
doaj   +1 more source

How to Inhibit Nuclear Factor-Kappa B Signaling: Lessons from Poxviruses

Pathogens, 2022
The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates key host inflammatory and antiviral gene expression programs, and thus, is often activated during viral infection through the action of pattern-recognition receptors and ...
Joshua B. Reus, Emily A. Rex, Don B. Gammon   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

International Journal of Molecular Medicine, 2011
Several kinds of sesquiterpene lactones have been proven to inhibit NF-κB and to retard atherosclerosis by reducing lesion size and changing plaque composition. The anti-malarial artemisinin (Art) is a pure sesquiterpene lactone extracted from the Chinese herb Artemisia annua (qinghao, sweet wormwood).
Yue, Wang, Zhouqing, Huang, Liansheng, Wang, Shu, Meng, Yuqi, Fan, Ting, Chen, Jiatian, Cao, Rujia, Jiang, Changqian, Wang   +8 more
openaire   +3 more sources

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis [PDF]

Cell Death & Differentiation, 2011
The ubiquitin-editing enzyme A20 (tumor necrosis factor-α-induced protein 3) serves as a critical brake on nuclear factor κB (NF-κB) signaling. In humans, polymorphisms in or near the A20 gene are associated with several inflammatory disorders, including psoriasis.
Declercq, Wim, Lippens, Saskia, Lefebvre, Sylvie, Gilbert, Barbara, Sze, Mozes, Devos, Michael, Vereecke, Lars, Mcguire, Conor, Guerin, Christopher J., Vandenabeele, Peter, Pasparakis, Manolis, Mikkola, Marja L, Beyaert, Rudi, van Loo, Geert, Verhelst, Kelly   +14 more
openaire   +3 more sources